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BRIEF REPORTS: REPUBLICATION
Year : 2017  |  Volume : 3  |  Issue : 3  |  Page : 112-114

Correlation between CCL20 and serum glucose in postoperative coronary bypass patient: A call for further investigation


1 Department of Medical Microbiology and Immunology, University of Toledo Medical Center, Toledo; Department of Anesthesiology, The Ohio State University Medical Center; Columbus, OH, USA
2 Department of Biomedical Engineering, University of Toledo College of Engineering, Toledo, OH, USA
3 Department of Medical Microbiology and Immunology, University of Toledo Medical Center, Toledo, OH, USA
4 Department of Anesthesiology, The Ohio State University Medical Center, Columbus, OH, USA
5 Department of Surgery, Division of Critical Care, Trauma, and Burn, The Ohio State University Medical Center, Columbus, OH, USA

Correspondence Address:
Thomas J Papadimos
Department of Anesthesiology, The Ohio State University Medical Center, Columbus, OH 43210
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/IJAM.IJAM_101_16

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Insulin administration during cardiopulmonary bypass grafting and in the perioperative period has been shown to lower tumor necrosis factor-α, interleukin-6 (IL-6), and IL-8 levels, which are considered to be mediators of immunity and inflammation. It is not known whether perioperative hyperglycemia attenuates the action of lymphocyte attracting chemokines such as (CC-motif) ligand 20 (CCL20), also known as macrophage inflammatory protein 3; or liver activation regulated chemokine. CCL20 is a selective chemoattractant for immature dendritic cells, effector/memory T lymphocytes and naïve B cells, and is recognized as a critical regulator of both innate and acquired immunity. In this report, we describe our preliminary findings of the interaction between serum blood glucose and CCL20. Specifically, we report an increase in CCL20 temporally associated with improving glycemic control in a diabetic patient undergoing intensive insulin therapy after open heart surgery. The following core competencies are addressed in this article: Medical knowledge. Republished with permission from: Papadimos TJ, Pappada SM, Lather JD, Bazalitski V, Stawicki SP, Cameron BD, Pan ZK. Correlation between CCL20 and serum glucose in postoperative coronary bypass patient: A call for further investigation. OPUS 12 Scientist 2010; 4(1):1-2.


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