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CASE-BASED REVIEW
Year : 2017  |  Volume : 3  |  Issue : 1  |  Page : 132-140

Part 2: The extracellular matrix in undiagnosed connective tissue disease


1 Department of Internal Medicine, Lewis Katz School of Medicine, Pennsylvania 18015, USA
2 Department of Anesthesiology, University of Pennsylvania, Pennsylvania 18015, USA
3 Department of Medicine, Lardy Hardinge Medical College, New Delhi, India
4 Department of Pathology, St. Luke's University Health Network, 801, Ostrum Street, Bethlehem, Pennsylvania 18015, USA
5 Department of Internal Medicine, St. Luke's University Health Network, 801, Ostrum Street, Bethlehem, Pennsylvania 18015, USA

Correspondence Address:
Sudip Nanda
Department of Internal Medicine, St. Luke's University Hospital Network, 801, Ostrum Street, Bethlehem, Pennsylvania 18015
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2455-5568.209846

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Connective tissue (CT) is essential for maintaining the functional integrity of the human body. Diseases due to CT malfunction are usually associated with deregulation at the molecular level, corresponding to essential components of the extracellular matrix (ECM). While many conditions have been identified and categorized, the complexity of the ECM yields many yet unclassified possibilities that could manifest as systemic disease. In this paper, we highlight a patient's presentation with systemic disease as a means to explore possible, unclassified ECM aberrations that hold promise as ubiquitous CT disruptors. The following core competencies are addressed in this article: Patient care, Medical knowledge.


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