Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 211
  • Home
  • Print this page
  • Email this page

 Table of Contents  
Year : 2018  |  Volume : 4  |  Issue : 2  |  Page : 124-141

Endoscopic retrograde cholangiography: Complications, emergencies, and related topics

1 Department of Family Medicine, St. Luke's University Health Network, Warren Campus, Phillipsburg, NJ, USA
2 Temple University School of Medicine, University Hospital Campus, Bethlehem, PA, USA
3 Department of Surgery, Section of Gastroenterology, St. Luke's University Health Network, Bethlehem, PA, USA
4 Department of Internal Medicine, Section of Gastroenterology, St. Luke's University Health Network, Bethlehem, PA, USA
5 Deparment of Surgery, Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA
6 Department of Surgery, The Ohio State University College of Medicine, Columbus, OH, USA
7 Department of Emergency Medicine, University of Florida, Jacksonville, FL, USA

Date of Submission31-Jul-2018
Date of Acceptance06-Aug-2018
Date of Web Publication30-Aug-2018

Correspondence Address:
Dr. Stanislaw P Stawicki
Department of Research and Innovation, St. Luke's University Health Network, EW2 Research Administration, 801 Ostrum Street, Bethlehem, Pennsylvania 18015
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/IJAM.IJAM_36_18

Rights and Permissions

Endoscopic retrograde cholangiopancreatography (ERCP) is a commonly performed procedure with both diagnostic and therapeutic indications. Following wider adoption of magnetic resonance cholangiopancreatography and endoscopic ultrasound, a shift emerged toward the interventional use of ERCP. Inherent to this shift was the evolution of procedural risk profile, resulting in a greater propensity for more severe periprocedural morbidity. Because ERCPs are so ubiquitous, it is imperative for medical and surgical practitioners to posses excellent knowledge of the risks, benefits, and therapeutic/diagnostic alternatives. The intent of the current manuscript is to provide an authoritative review on the topics of ERCP-related complications, emergencies, and related subject matter.
The following core competencies are addressed in this article: Patient care and procedural skills, Medical knowledge, Practice-based learning and improvement.

Keywords: Cholangitis, complications, diagnosis and management, endoscopic retrograde cholangiopancreatography, pancreatitis, sphincterotomy, stenting

How to cite this article:
Wojda TR, Nuschke JD, Smith EA, Modi R, Schadt S, Strosberg D, Geme B, Galwankar SC, Stawicki SP. Endoscopic retrograde cholangiography: Complications, emergencies, and related topics. Int J Acad Med 2018;4:124-41

How to cite this URL:
Wojda TR, Nuschke JD, Smith EA, Modi R, Schadt S, Strosberg D, Geme B, Galwankar SC, Stawicki SP. Endoscopic retrograde cholangiography: Complications, emergencies, and related topics. Int J Acad Med [serial online] 2018 [cited 2022 Aug 17];4:124-41. Available from: https://www.ijam-web.org/text.asp?2018/4/2/124/240137

  Introduction Top

Endoscopic retrograde cholangiopancreatography (ERCP) is a commonly performed diagnostic and therapeutic procedure [Figure 1]. It is arguably one of the most complex endoscopic procedures.[1] With increasing use of other advanced diagnostic modalities such as endoscopic ultrasound (EUS) and magnetic resonance cholangiopancreatography (MRCP), the role of ERCP shifted toward more interventional indications.[2],[3] As with any modality that carries a defined risk of morbidity, the appropriateness of ERCP depends heavily on the practitioner's understanding of the risk-benefit equation informed by available clinical evidence.[4],[5],[6] Reluctance by many endoscopists to utilize ERCP liberally is well justified given a wide variety of potential procedural complications and corresponding risk factors.[6],[7] The goal of this manuscript is to provide a reappraisal of existing literature regarding ERCP-related morbidity, focusing on known risk factors and preventive strategies.
Figure 1: Examples of endoscopic retrograde cholangiopancreatography utilization in typical endoscopy practice. (Top left) Biliary stone extraction procedure. Stone in the common bile duct (large arrow) and a guidewire in the right hepatic duct (small arrow). (Top right) Deployment of “double pigtail” endoscopic stent in the common bile duct (large arrow). Dilated intrahepatic ducts (small arrow) can be seen. (Bottom left) Balloon stone extraction (large arrow) from the common bile duct. Note the guide wire in the right hepatic duct (small arrow). (Bottom right) Normal endoscopic retrograde cholangiopancreatography with good visualization of the cystic duct (large arrow)

Click here to view

  Endoscopic Retrograde Cholangiopancreatography: Clinical Indications and Contraindications Top

Diagnostic and therapeutic indications

Diagnostically, ERCP has revolutionized clinical management of both malignant and benign pancreatic/biliary conditions,[8],[9] with the added benefit of obtaining cytological samples for tissue examination.[10],[11] From therapeutic perspective, ERCP is effective in the management of common bile duct (CBD) stones,[12] benign biliary strictures,[13] bile duct leaks,[14] ampullary adenomas,[15]  Sphincter of Oddi More Details dysfunction (SOD),[16] transpapillary bile duct drainage,[17] and malignant biliary obstruction.[18] ERCP has also been described as useful in the management of pancreatic divisum,[19] anomalous pancreaticobiliary union,[20] type 3 choledochal cyst (e.g., choledochocele),[21] annular pancreas, and cystic duct insertion into the papilla.[22] Chronic pancreatitis[23] and pancreatic duct (PD) leaks may also be treated with ERCP.[24] Patients with Billroth II surgical reconstruction or pancreaticoduodenectomy were once considered high risk for ERCP; however, ERCP in Post-Whipple anatomy and Roux-en-Y anastomoses has been successful (albeit technically challenging).[25]


Absolute contraindications to ERCP include the presence of any clinical condition that is prohibitive of effective sedation (e.g., hemodynamic instability), uncorrected coagulopathy, decision by a competent patient to not consent for a procedure, as well as the lack of an adequately trained endoscopist.[26] In addition, pharyngeal or esophageal obstruction, hypersensitivity to iodinated contrast medium, and existing visceral perforation are also considered contraindications.[7],[27] There is continued controversy regarding the use of “immediate” ERCP in acute biliary pancreatitis, with lack of standardized approach in this particular setting.[28],[29]

Relative contraindications include advanced patient frailty[30] and various anatomical conditions (e.g., gastroduodenal disease or surgical alteration that prohibits endoscopic access to the major papilla).[31] Structural abnormalities of the esophagus, stomach, or small intestine may constitute relative contraindications for ERCP. Such conditions include but are not limited to anatomic changes such as esophageal stricture, paraesophageal hernia, esophageal diverticulum, gastric volvulus, and gastric outlet obstruction.[7] In addition, transient conditions such as gastric or duodenal perforation, as well as small bowel obstruction, also constitute contraindications.[7] Some also consider portal hypertension featuring esophageal and/or gastric varices, acute pancreatitis (except gallstone pancreatitis), recent myocardial infarction, and severe cardiopulmonary disease as relative contraindications.[26],[32]

  Alternatives to Endoscopic Retrograde Cholangiopancreatography Top

Magnetic resonance cholangiopancreatography

ERCP is considered the gold standard for diagnosis of choledocholithiasis (CDL) with excellent sensitivity (90%–97%) and specificity (95%–100%).[33] However, in light of the increased usage of less invasive imaging techniques, multiple studies have examined the reliability of MRCP and EUS in the setting of CDL. A comprehensive meta-analysis showed that, when the diagnosis of CDL is in question, MCRP represents a highly accurate, lower risk imaging alternative.[34] The reported high sensitivity (81%–100%), specificity (94%–98%), and diagnostic accuracy (94%–97%) of MRCP make this option very attractive.[35],[36],[37],[38]

Typical MRCP examinations include a T1-weighted in-phase/out-of-phase spoiled gradient echo sequence, one or more T2-weighted sequences, and a dynamic contrast-enhanced fat-saturated spoiled gradient echo sequence.[39],[40] MRCP is often able to define biliary anatomy in situ ations where ERCP or percutaneous transhepatic cholangiography (PTC) may have failed or are unsuitable.[41] T1-weighted MRCP using hepatocyte-specific intravenous (IV) contrast agents (e.g., mangafodipir trisodium or gadoxetate disodium) excreted into bile provides sufficient functional and anatomic information to identify active bile leaks.[41] MRCP with concurrent IV secretin administration to stimulate exocrine fluid excretion may improve diagnostic yield in chronic pancreatitis.[42] In addition, MRCP can provide valuable clinical information in cases where endoscopic retrograde contrast injection failed to pass a tight stenosis/stricture.[43] The failure rate of ERCP in patients with previous biliary-enteric anastomosis or gastroenteric drainage procedures ranges from 10% to 48%.[44] In such patients, MRCP provides excellent visualization of the biliary-enteric anastomosis, intrahepatic ducts, as well as details regarding any anatomic abnormalities (e.g., strictures and masses). This, in turn, helps guide any further interventions.[45],[46]

Despite its many advantages, MRCP has several potential pitfalls. First, substantial radiology expertise is required when interpreting studies, especially in the context of potential imaging artifacts obscuring biliary anatomy.[47] Second, MRCP provides a static representation of the biliary anatomy, as opposed to ERCP which is dynamic.[48] Although high-quality dynamic MRCP sequences may help circumvent this limitation, they are difficult to obtain.[48] Further optimization of pancreatic and biliary ductal visualization can be achieved using the axial 2D FIESTA (fat suppressed) sequences.[48] Third, differentiation between ascites, perihepatic fluid collections, and edema may be difficult, especially on noncontrast MRCPs in the setting of acute inflammation.[41] Fourth, there is potential for mistaking a stone for another type of intraluminal filling defect (e.g., pneumobilia, intraductal tumor, or blood clot).[49]

Overall, clinical risks of MRCP are minimal. Factors that prohibit the conduct of MRCP include the presence of implanted metallic objects/foreign bodies deemed unsafe for magnetic exposure levels encountered during an magnetic resonance imaging (MRI). Gadolinium-associated nephrogenic systemic fibrosis may occur on rare occasion.[50],[51] Finally, patients who experience claustrophobia may not tolerate MRI due to associated anxiety.[52] In terms of benefits to the patient, MRCP allows relative risk reduction due to the avoidance of unnecessary ERCPs. This becomes apparent when looking at traditional risk assessment schemes for hepatobiliary disorders and their ability to predict “therapeutic or diagnostic” ERCP.[41] In one study, information specific to liver function profile lacked specificity and resulted in a >50% incidence of negative ERCPs.[53] Due to ERCP-associated morbidity of 3%–9% and mortality of 0.2%–0.5%,[54] MRCP verification of the presence of biliary stones was suggested as the optimal diagnostic approach with highest clinical utility, reserving endoscopy (and thus ERCP-related complication risk) for a much smaller patient group who are much more likely to benefit from a therapeutic intervention.[7]

Computed tomography cholangiography

Traditional unenhanced computed tomography (CT) imaging of the biliary tree provides information regarding the presence of calcified ductal calculi, while CT utilizing IV contrast may provide indirect evidence of noncalcified stones.[55] Contrast-enhanced CT cholangiopancreatography (CTCP) can be facilitated either through direct or indirect contrast medium injection and is relatively easier to obtain than MRCP in acutely ill patients who require close monitoring.[55] Direct CTCP requires biliary injection of contrast agent through either percutaneously or enterally introduced catheter (with EUS or ERCP assistance).[54],[56] Positive-contrast CTCP uses iodipamide meglumine given intravenously over 30 min, with an addition of IV hyoscine to relax the sphincter of Oddi right before acquiring images.[54] Indirect CT cholangiography reportedly has sensitivity and specificity in excess of 90%.[57] Benefits of CTCP include lower susceptibility to imaging artifact than MRCP and relatively higher definition of biliary anatomy.[54] With the advent of minimal intensity projection reconstruction techniques, CTCP utilizes bile itself as a “negative contrast” within the lumen of biliary tract.[58]

Percutaneous transhepatic cholangiography

PTC allows for highly accurate evaluation of biliary anatomy including direct diagnostic and therapeutic management of biliary pathology.[59],[60] Performed under sterile procedural conditions, PTC involves placement of a small gauge needle into peripheral biliary conduits using imaging guidance, followed by contrast material injection.[60] PTC carries significant potential complications, the rate of which depends on preprocedure patient status and diagnosis.[59] For example, patients with coagulopathy, cholangitis, biliary ductal stones, malignant, or proximal obstruction will have higher complication rates with the more invasive PTC diagnostic option.[61]

Endoscopic ultrasound

EUS is a more invasive procedure than MRCP or CT cholangiography. At the same time, EUS facilitates the examination of the entire length of the CBD from the level of duodenal bulb. In one randomized trial, the use of EUS in suspected CDL cases was associated with shorter procedure times, fewer complications, and was more cost effective due to the avoidance of unnecessary ERCP examinations.[62] EUS has been shown to have sensitivity of 94% and specificity of 95% for CDL.[63] It is also very sensitive for the diagnosis of gallbladder sludge, cholelithiasis, and microlithiasis. EUS with fine-needle aspiration (FNA) has been shown to have a higher diagnostic yield in certain pancreaticobiliary malignancies,[64] likely due to the ability to better target suspicious lesions. Moreover, EUS with needle puncture and guide-wire placement can help facilitate biliary access from either the duodenum (e.g., CBD) or the stomach (e.g., left hepatic lobe). This may become an important option when initial ERCP has failed or is not feasible.[65] Finally, the combination of EUS with FNA and ERCP may be considered in the evaluation of selected patients with obstructive jaundice.[66] The reported complication rate of such approach is comparable to component procedures.[66]

  Quantifying the Prediction of Choledocholithiasis Top

As previously stated, ERCP is most commonly used in the management of CDL. Because no single indicator seems to reliably predict the pre-ERCP presence of biliary stones, strategies are needed to better optimize ERCP use, thus preventing unnecessary procedural morbidity. One strategy focuses on stratifying clinical probability of CDL in the setting of symptomatic cholelithiasis.[67],[68],[69],[70],[71],[72] Clinical predictors may help stratify risk of CDL into “high” (>50%), “intermediate” (10%–50%), or “low” (<10%). CBD stone on ultrasound, clinical ascending cholangitis, and bilirubin >4 mg/dL are considered “very strong” predictors. Dilated CBD on ultrasound (>6 mm) without a history of cholecystectomy and bilirubin of 1.8–4 mg/dL are considered “strong” predictors. Abnormal liver biochemistry, age >55 years, and clinical gallstone pancreatitis are considered “moderate” predictors. The presence of any very strong predictor or both strong predictors indicates “high likelihood” (>50%) of CDL. At the same time, the presence of fewer predictors places the patient at “intermediate risk” (10%–50%) of CDL. The presence of no predictors places the patient at a “low risk” (<10%) of CDL. Consequently, ERCP should be recommended only when its benefits outweigh the risks (e.g., when there is a higher likelihood of CDL and therapeutic intervention).[67],[68],[69],[70],[71],[72] Thus, EUS, intraoperative cholangiogram, or MRI/MRCP is recommended before ERCP in the setting of “intermediate” risk based on the above predictors. Patients at “low risk” of CDL can undergo cholecystectomy for symptomatic cholelithiasis without ERCP or further evaluation.[67],[68],[69],[70],[71],[72]

  Endoscopic Retrograde Cholangiopancreatography: the Equipment Top

ERCP combines endoscopy and radiography to visualize the hepatobiliary tree and PDs.[73] Many centers have designated rooms and personnel to help facilitate the procedure; however, portable imaging equipment can be utilized if necessary. Basic equipment setup consists of a light source, side-viewing endoscope, an assortment of cannulating catheters, with accompanying video display, and high-resolution fluoroscopy.[74],[75] The side-viewing video scope is equipped with an elevator that facilitates cannulating the papilla of Vater.[76] In addition to a control head which maneuvers the distal end, the endoscope also has ports for air insufflation, irrigation, and typically a 4.2 mm or 4.8 mm diameter working channel. This working channel facilitates various therapeutic maneuvers during ERCP procedures. A variety of accessories can be utilized through the working channel including guidewires, sphincterotomes, drainage devices, stents, as well as tissue sampling and stone extraction devices.[77],[78],[79]

  Endoscopic Retrograde Cholangiopancreatography: Preparation for Procedure Top

Before ERCP, a plain abdominal radiograph should be obtained to identify any artifacts, residual contrast material, or calcifications that may be superimposed and interfere with fluoroscopy interpretation. A thorough review of any other previous imaging (e.g., CT or MRI) is also mandatory (e.g., to identify changes such as Roux-en-Y anatomy).[80],[81] Routine pulse oximetry is recommended for all patients and a resuscitation cart should be readily available.[7],[82] Patients scheduled for ERCP should avoid solid food for 6–8 h before the procedure. This will help minimize aspiration risk and maximize intraluminal visualization. If ERCP with sphincterotomy is to be performed, antithrombotic medications should be held to minimize the risk of bleeding. Although the routine use of antibiotics is not recommended,[83] their use should be reserved for cases characterized by preexisting obstructive bile duct disease.[84] In addition, antibiotic prophylaxis should be utilized in patients at high risk of developing infective endocarditis such as those with prosthetic cardiac valve, history of infective endocarditis, cardiac transplant recipients, or patients with congenital heart disease.[85],[86] It is not recommended that patients with orthopedic implants receive antibiotics, but solid organ transplant recipients and other immunosuppressed populations should receive prophylaxis before ERCP.[86],[87] Debate continues regarding the optimal choice of antimicrobial prophylactic agent.[88]

  Endoscopic Retrograde Cholangiopancreatography: Technical Considerations Top

After conscious sedation is initiated, the patient is placed in the left lateral position. This position is both comfortable for the patient and facilitates rotational changes required to evaluate ductal anatomy in different planes.[89] Analgosedation is usually achieved using a combination of parenteral conscious sedation and a topical anesthetic applied to the posterior oropharynx.[7] The side-viewing scope is then passed through a bite block into the oropharynx and advanced through the esophagus.[90] If unexpected resistance is encountered during the scope insertion or passage, the endoscopist is advised to stop and switch to a forward viewing endoscope to visualize any abnormalities such as a Zenker's diverticulum or a stricture, thus preventing a potential injury or perforation.[79],[91] It is preferable to advance the duodenoscope under direct visualization to identify key landmarks such as the cardia, incisura, and pylorus. However, care should be taken to avoid excessive insufflation, as accentuation of a J-shaped stomach may make it difficult to navigate the pylorus.[92],[93],[94] Once the endoscope has been advanced through the pylorus, it is positioned in the second portion of the duodenum, with additional maneuvers (beyond the scope of this review) utilized to maximize the visualization of the papilla.[92] The papilla is then identified and inspected, with the endoscopist setting up optimal conditions before cannulation. Before any intraductal manipulations, the operator should flush all endoscopic access devices to prevent the injection of air (e.g., intraductal air may appear similar to a retained gallstone and thus create diagnostic uncertainty).[95],[96],[97] In cases of difficult cannulation, the use of a hydrophilic guidewire with concurrent glucagon administration can help improve success rates.[7] It is strongly advised to limit the number of attempts to avoid injury at the cannulation site and the subsequent development of tissue edema.[98] Following successful access to the ductal system, a variety of instruments can be introduced through the working channel of the endoscope. Plastic stents are utilized to facilitate drainage, while self-expandable metal stents have greater utility in the setting of malignancy since they tend to provide better long-term patency.[99],[100] Tissue sampling techniques have also been developed, including highly advanced endoscopic biopsy forceps and miniaturized brush cytology devices.[101],[102],[103] Biliary dilation balloons can be used in the management of strictures.[104] Stone retrieval can be facilitated using a variety of accessories such as specialized endoscopic baskets, mechanical lithotripters, and other highly customized catheters.[105],[106],[107] Intraductal ultrasound provides “real-time” evaluation of biliary strictures and surrounding vascular structures. High frequency ultrasound probes have been used to evaluate biliary strictures, small stones, or sludge.[108],[109],[110] Finally, endoscopic sphincterotomy during ERCP involves deep cannulation of the bile duct followed by the application of electrocautery to incise the sphincter of Oddi. Beyond the scope of the current discussion, the procedure involves the use of devices known as sphincterotomes or papillotomes.[111],[112],[113]

  Overview of Endoscopic Retrograde Cholangiopancreatography Complications Top

Any invasive procedure will carry some risk of associated morbidity. Consequently, the overarching goal should be to minimize – and if possible eliminate – any procedure-related adverse events. In addition to intimate knowledge of specific complications, the critical step in preventing post-ERCP morbidity is to promptly recognize at-risk patients.[1],[114],[115],[116],[117],[118] [Table 1] summarizes major risk factors for ERCP-related complications including reported odds ratios.[1],[114],[119] In addition, the clinical success and safety of ERCP are closely related to experience, training, and skill of the operator, as outlined in published guidelines regarding minimal experience required to maintain competence.[120] Endoscopists who perform <200 ERCPs annually have been shown to experience increased number of adverse events.[1],[116],[118] Depending on the indication for procedure, the overall ERCP complication rate can vary from <5% to as high as 40%.[14],[17],[44],[45],[121] In one study, the incidence of mild complications (requiring 1-4 additional hospital days) was approximately 4.5%, with more significant events accounting for about 5% of complications.[25] ERCP complications may also be grouped into short-term (occurrence within 3 days after the procedure) and long-term (occurrence >3 days postprocedure) event categories[7] Examples of short-term morbidities include sedation-related events or intraprocedural bowel perforation. Long-term complications, on the other hand, may be related to indwelling stent infections and inflammatory changes from ductal handling.[7]
Table 1: Risk factors of endoscopic retrograde cholangiopancreatography-related adverse events and associated odds ratios; data compiled from all available reports included in this review

Click here to view

Therapeutic ERCP is more likely to be associated with complications than diagnostic ERCP; however, neither approach is free of morbidity.[25],[122] Mortality attributable to ERCP may be as high as 0.5%, with therapeutic ERCP carrying greater risk than diagnostic ERCP, at 0.5% and 0.2%, respectively.[2],[25] Predictors of severe or fatal complications of ERCP include male gender, American Society of Anesthesiologists Grade III or greater, obesity, suspected or known ductal stone, SOD, therapeutic and urgent procedures, trainee involvement, as well as more technically difficult cases.[121] [Table 2] shows a more comprehensive list of both short- and long-term complications, along with reported incidence range(s).[123] Further information on various ERCP-related morbidity, including severity grading for bleeding, perforation, pancreatitis, and infection, the reader is referred to the work by Cotton et al.[121]
Table 2: Periprocedural, short- and long-term complications of endoscopic retrograde cholangiopancreatography; data compiled from all available sources used in this report

Click here to view

  Endoscopic Retrograde Cholangiopancreatography-Associated Pancreatitis Top

Acute pancreatitis is among the most common ERCP-related complications. The incidence range of ERCP-associated pancreatitis (EAP) is between 1% and 10% in the overall reported experience but may be >30% in certain high-risk patients.[114],[124],[125] Precise incidence of EAP is difficult to estimate because anywhere between 25% and 75% of patients who undergo ERCP may experience postprocedural increase in serum amylase levels.[126],[127] In one report, the incidence of clinical pancreatitis after diagnostic and therapeutic ERCP was 3% and 7%, respectively.[128] However, the performance of diagnostic versus therapeutic ERCP does not seem to be a major predictor of EAP, with some authors describing higher incidence of EAP after diagnostic (5.2%) compared to therapeutic (4.1%) procedures.[129] Severe pancreatitis has been reported to occur following approximately 1% of ERCP procedures.[126]

Due to a relatively large number of ERCP procedures being associated with “benign elevations” of pancreatic enzymes, objective criteria were introduced to differentiate the more benign occurrences from the clinically significant EAPs.[130] The diagnosis of EAP can be made if 2 of 3 diagnostic criteria are met: Presence of epigastric pain, amylase or lipase >3 times the upper limit of normal, or cross-sectional imaging showing pancreatic inflammation. EAP is considered mild if 2–3 days of additional hospitalization are required, moderate with 4–10 days of hospitalization, and severe if the patient requires >10 days of additional hospitalization, drainage of a pseudocyst, or a pancreatic phlegmon is present.[131] The determination of EAP should always be made in the context of the overall risk profile of the ERCP procedure.[1],[114],[132] Summary of both Cotton criteria (designed for post-ERCP pancreatitis) and Revised Atlanta Classification criteria (applicable to all pancreatitis cases) are shown in [Table 3].[133],[134]
Table 3: Classifications utilized for grading the severity of all pancreatitis cases (Revised Atlanta) and postendoscopic retrograde cholangiopancreatography pancreatitis (Cotton)

Click here to view

Several mechanisms associated with the genesis of EAP have been proposed including thermal injury from electrocautery, hydrostatic injury from contrast injection “overpressure” within the PD, chemical injury from either intestinal enzymatic content or radiographic contrast, and mechanical injury from prolonged manipulation around the papillary orifice and the associated tissue edema.[135] Three large prospective studies have reported risk factors for EAP. These have been broadly categorized as patient, operator, or procedure specific and will be discussed in more detail in subsequent paragraphs.

Patient-related factors include younger age,[132] female gender, history of acute or recurrent pancreatitis,[136] previous history of EAP, preexisting biliary-type pain, the presence of CDL, normal serum bilirubin, and suspicion of SOD (especially type III dysfunction with normal bile duct size and normal hepatic function tests).[119] Of note, there is no firm evidence that periampullary diverticulum, pancreatic divisum, allergy to contrast media, or small caliber bile duct confer additional risk of EAP.[135]

Operator-dependent risks of EAP include low case volume, provider experience, and various technical factors.[132] High volume endoscopists have been noted to have fewer PD injections and greater overall procedural success, but the correlation between endoscopist-specific volumes and the rate of EAP is not fully understood.[136],[137],[138] Operator-related risks are difficult to study because of the presence of various potential confounders including differences between patient populations and procedural indications between various providers, institutions, and geographic regions.[138] Consistent with the relationship between provider case volumes and complications, trainee participation appears to increase the risk of EAP.[132]

Procedure-specific risk factors for EAP include difficult cannulation of the ampulla of Vater (e.g., multiple attempts required),[136],[139] cannulation of the PD,[137] repeated injections of contrast into the PD,[140] PD sphincterotomy,[141] pancreatic acinarization (opacification of acini),[142] PD tissue sampling/brushing,[143] pneumatic dilation of an intact biliary sphincter,[144] precut sphincterotomy,[145] and ampullectomy.[146] One study suggested that patients with opacification of the pancreatic head had lower levels of pancreatitis than those with pancreatic tail opacification.[142] Further, acinarization, which occurs when pancreatic acini are opacified by a high-pressure injection, may pose some additional risk as well.[137]

Careful assessment of potential risks and benefits should be performed before performing even the most “routine” ERCP procedure. This is because the overall procedural risk may be a reflection of several factors acting synergistically. For example, the combination of SOD, difficult cannulation, and normal size ducts may result in disproportionately elevated risk of EAP.[119] Others reported that ERCPs performed in patients <60 years of age, using precut sphincterotomy, and complicated by an inability to clear biliary stones, carried significantly elevated EAP risk.[114] Mehta et al. found a 27% risk of EAP in patients <59 years who had a sphincterotomy with no stone identified in the CBD.[12] Further, age <70, with PD opacification, and nondilated CBD increased risk in another report.[1]

Rates of EAP increase significantly depending on the number of cannulation attempts. For instance, for <5, <10, and <15 attempts, corresponding EAP rates were 3%, 7%, and 13%.[137] For more challenging cases of cannulation, a “precut” or access papillotomy may be performed to gain entry into the bile duct.[147] This method utilizes a bare wire plus cautery to access the duct when traditional cannulation is difficult or not possible.[93] There is controversy regarding this approach and the associated risk of EAP.[148] One could speculate that the increased risk likely relates to the number of cannulation attempts performed before the precut technique is attempted. Because sphincterotomy is not indicated in patients with coagulopathy, the sphincter may be dilated with a balloon, or a stent may be placed. However, higher rates of pancreatitis have been reported with balloon dilation.[144] Consequently, balloon dilation should be reserved for patients who are not candidates for sphincterotomy. If the need for “precut” is determined, simultaneous stent use is recommended. Furthermore, proactive risk-benefit assessment between successive cannulation attempts is strongly encouraged, primarily because early use of “precut” may help reduce such attempts (and presumably decrease associated morbidity).[127]

There is an ongoing debate regarding the use of electrocautery during ERCP procedures and the risk of pancreatitis. In one study, 170 patients were randomized to either “pure cut” or blended current for biliary sphincterotomy, with significantly lower risk of pancreatitis for “pure cut” (3%) than blended current (10%).[149] However, a larger nonrandomized trial suggested differently.[127] Others found that the use of monopolar cautery was associated with lower risk of EAP than bipolar cautery.[150]

Historically, SOD is associated with substantial risk (24%) of EAP following diagnostic or therapeutic ERCPs.[151] Stent placement, which promotes ductal drainage, may reduce this particular risk by nearly 75% (from 26% to 7%).[152] In addition, modern catheters featuring modified perfusion ports are also associated with substantially reduced risk of EAP (from >30% to <5%).[153] Newer microtransducer catheters favorably modulate the risk of EAP even further.[154] Aspiration type catheters (where fluid is constantly aspirated from the PD) may also be of value. Of note, biliary sphincterotomy alone in patients with SOD was associated with similar pancreatitis rates (~20%) when compared to simultaneous manometry and sphincterotomy (~18%).[137]

Obstruction of pancreatic secretion outflow from papillary edema, cannulation, or thermal sphincterotomy injury may induce EAP. This may be remedied by transsphincteric PD stenting.[155],[156],[157] As stated in the previous paragraph, stent placement may help reduce the risk of pancreatitis.[152] At the same time, one must be cautious when placing a pancreatic stent because failed placement may increase the risk of EAP[158] and stenting itself may be associated with ductal injury and/or stricture formation.[159],[160],[161] Indications for the placement of prophylactic stent include (a) suspected SOD, (b) ampullectomy, (c) placement of pancreatic guidewire to aid biliary cannulation, (d) multiple PD injections, (e) repeated PD cannulations, (f) pancreatic endotherapy, (g) history of prior EAP, and (g) the use of “precut” sphincterotomy.[135]

Data regarding the optimal characteristics of stents used for prophylaxis are mixed.[162] It is likely that the size of stent is important since smaller stents cause less injury than larger ones.[163] Use of 4 French and 5 French straight stents placed over conventional wires positioned within the PD may be preferred.[156],[164],[165] Following stent placement, abdominal radiographs should be taken 1–2 weeks later to ensure that it has not migrated. Ductal perforation, proximal stent migration, and repeated placement attempts leading to pancreatitis are all possible.[166],[167],[168] Therefore, stents should only be used in appropriate risk patients.

The use of endoscopic balloon is one alternative to sphincterotomy for the removal of intraductal gallstones.[144] This methodology is somewhat controversial, with mixed evidence regarding associated clinical outcomes. According to some studies, there is no increase in morbidity when using this approach.[169],[170] However, others have demonstrated increased risk of EAP.[137] Consequently, balloon dilation should be used in selected cases only.

  Medical Prevention of Endoscopic Retrograde Cholangiopancreatography-Associated Pancreatitis Top

Various prophylactic modalities for EAP have been proposed, with somewhat mixed results. General strategies in this area include the reduction of pancreatic inflammation, lowering of exocrine activity, and better control of pressures applied to the sphincter of Oddi.[171],[172],[173] Somatostatin and octreotide decrease pancreatic secretions and minimize pancreatic hypertension;[174],[175] however, somatostatin does not seem to be effective in preventing EAP.[176] The use of gabexate mesilate, a protease inhibitor, has been associated with lower postprocedural amylase levels, favorable abdominal pain profile, and decreased pancreatitis frequency.[177] Despite that, a multicenter study of 579 patients failed to demonstrate benefits of gabexate or somatostatin infusion.[178]

Nonionic contrast agents have not reduced the incidence of pancreatitis while increasing study costs.[179],[180] Although previously considered helpful, periprocedural administration of corticosteroids,[181] nifedipine[182] and allopurinol have all been been shown not to be beneficial.[183] Interleukin-10 (IL-10) has known anti-inflammatory properties, with a single study documenting potential benefits of single IV dose administration (4 or 20 μg/kg) at approximately 30 min before ERCP.[184] However, a subsequent study failed to demonstrate benefit when IL-10 was infused at a rate of 8 μg/kg immediately before ERCP.[185] Another report found that low-molecular-weight heparin use fails to lower EAP rates.[186]

Nitroglycerin, known to reduce pressure at the sphincter of Oddi, was associated with lower incidence of EAP in two clinical studies; however, it should be used with caution because of the potential for systemic hypotension.[187],[188] In a more recent report, diclofenac suppository given 30–60 min preprocedure and somatostatin 0.25 mg/h for 6 h postprocedure were shown to reduce EAP risk.[135] However, Cheon et al.[189] reported that prophylactic oral administration of diclofenac did not appear to reduce the frequency or severity of EAP in a randomized, double-blind study of high-risk patients. Another randomized trial featured the administration of 100 mg of indomethacin rectally to high-risk patients undergoing ERCP, with pancreatitis rates of 9.2% in the treatment group versus 16.9% in the control group.[135] However, the study may contain some biases since many patients also underwent prophylactic stent placement.

  Clinical Management of Endoscopic Retrograde Cholangiopancreatography-Associated Pancreatitis Top

Treatment of EAP is analogous to pancreatitis secondary to other etiologies. Key components of management include IV hydration, pain control, general supportive care, and the provision of adequate postduodenal nutritional intake.[190],[191] Rescue pancreatic stent placement or replacement for “salvage” of EAP has been described and may be considered in selected cases.[192] Much like the initial diagnosis of EAP, the final determination of clinical resolution is similar to that of pancreatitis associated with other etiologic factors.

  Post-Endoscopic Retrograde Cholangiopancreatography Hemorrhage Top

Post-ERCP hemorrhage [PEH, [Figure 2]]is primarily a complication of sphincterotomy or another procedural intervention during ERCP.[193],[194] Bleeding occurs in 1%–4% of patients during or after ERCP and is associated with mortality of approximately 0.3%.[137],[193],[194],[195],[196] Early PEH can appear within 24 h to 10 days.[137] Delayed bleeding may be seen in 50% of cases and may occur as long as 1–2 weeks after the index procedure.[123],[197] The presence of bleeding during the initial examination is predictive of delayed bleeding.[137] Clinically significant PEH can present with melena, hematemesis, or a drop in hemoglobin, and may require transfusion, additional endoscopic intervention, or surgical therapy.[137],[197] PEH can be classified as mild, moderate, and severe.[133] The corresponding objectified criteria include (a) drop in hemoglobin of <3 g/dL (mild); (b) transfusion requirements <4 units of packed red blood cells (PRBCs) with no intervention (moderate); and (c) transfusion requirements >4 units of PRBCs or intervention (severe).[133] The risk of severe hemorrhage is estimated to be 0.1%–0.5%.[1],[137]
Figure 2: An example of severe hemorrhage from the upper margin of the sphincterotomy site. Source: Di Pisa M, et al. Gastroenterol Res Pract 2010;2010:138748. Image used in accordance with the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Click here to view

Established risk factors for PEH include anticoagulants administered within 3 days of sphincterotomy, active coagulopathy, cholangitis before ERCP, initial bleeding at the time of sphincterotomy, obstructed papilla, and the use of “precut” sphincterotomy.[120],[198] The use of aspirin, nonsteroidal anti-inflammatory drugs, the creation of a longer incision, or enlarging a preexisting sphincterotomy have not been shown to be predictive of bleeding.[137]

If biliary drainage is required in a patient who is therapeutically anticoagulated and/or has an elevated international normalized ratio, stent placement without sphincterotomy may be warranted. A sphincterotomy may then be performed once risk factors are appropriately ameliorated. Heparin may be used if it is necessary to continue anticoagulation; however, warfarin (and other long-term anticoagulation agents) should be withheld around the time of procedure.[199],[200]

The use of a “smart electrocautery generator,” avoidance of sphincterotomy in high-risk cases, and using balloon dilatation may help reduce the risk of bleeding.[7] If the presence of bleeding is noted at the time of sphincterotomy, it is advisable to complete the sphincterotomy because thermal coagulation generally stops further bleeding. However, if bleeding continues, epinephrine injection (1:100,000 solution followed by direct injection of 1:10,000 solution for persistent hemorrhage) of the sphincterotomy site may achieve hemostasis.[201],[202] In addition, balloon tamponade may be sufficient in cases of bleeding without active coagulopathy. Argon plasma coagulation and thermal coagulation with heater probes or hemostatic clips may also help control bleeding.[198],[203] If hemorrhage persists angiography and placement of coils may be considered, although these are needed much less frequently.[198]

  Enteric Perforation during Endoscopic Retrograde Cholangiopancreatography Top

Free air following ERCP has been noted in nearly 30% of otherwise asymptomatic patients, making the determination of “clinical significance” the key factor when deciding how aggressive management should be.[123],[204],[205] Clinically significant ERCP-related perforations occur in approximately 0.3%–0.6% of procedures [Figure 3].[7],[206] Risk factors for perforation include concurrent performance of sphincterotomy, the presence of Billroth type II anatomy, intramural injection of contrast dye, dilation of biliary stricture, SOD, and longer procedure duration.[1],[7],[207],[208] Three major mechanisms of injury associated with perforations have been reported: guidewire-associated events, periampullary perforations during sphincterotomy, and perforations that occur outside of the papillary area.[7],[133],[206],[208],[209]
Figure 3: Computed tomography findings associated with duodenal perforation: (a) abdominal computed tomography showing large/complex fluid/air collection in the retroperitoneum; (b) abdominal computed tomography showing a large amount of retroperitoneal air. Source: Park SM. Clin Endosc 2016; 49 (4): 376-382. Figure used in accordance with the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited

Click here to view

The incidence of retroperitoneal perforations associated with sphincterotomy may be minimized by limiting wire contact with tissue and using cautery current judiciously and carefully.[137],[207],[210] In addition to being able to assist in determining key anatomical features during ERCP, fluoroscopy may help discern the presence of perforation well ahead any clinical manifestations.[206] Treatment may involve nasobiliary or nasopancreatic ductal stenting, nasogastric decompression, IV antibiotics, and holding oral nutritional intake. Diagnosis is usually confirmed with radiography or the more sensitive CT imaging, with or without oral contrast. Of importance, it has been demonstrated that hemoclips used during the procedure may seal sphincterotomy-induced perforations.[211] Nonoperative management is sufficient for vast majority of perforations, and clinical resolution may be seen in nearly 80% of patients.[207] Surgical consult is warranted in the setting of enteric perforation, principally due to the potential for clinical worsening that may require subsequent operative repair. If patient condition worsens or the perforation fails to seal despite optimized nonoperative management, surgery may be needed. The more optimized the approach, the better the outcome.[207]

Esophageal, gastric, and duodenal iatrogenic perforations are usually more extensive, generally associated with features such as luminal obstruction or surgically altered anatomy, often recognized late, and more likely to require surgery.[212],[213],[214] More than half of all perforations are associated with abnormal anatomy such as Zenker's or epiphrenic diverticula, as well as benign or malignant strictures.[215],[216],[217] In addition, the three points of esophageal narrowing – cricopharyngeus muscle, aortic knob, and diaphragmatic hiatus – may be associated with an increased risk of perforation.[82],[218] Diagnosis can be confirmed with plain radiography, but CT is warranted if any doubts remain.

Initial management of ERCP-related perforations consists of IV fluid resuscitation, broad-spectrum antibiotics, withholding oral intake, and nasogastric decompression.[207],[219],[220] When indicated, percutaneous drainage or surgical repair may all be required.[205],[207] Nonoperative approaches may be sufficient for contained perforations; however, any presence of free contrast extravasation or signs of sepsis necessitate surgical intervention.[82],[219],[221],[222] If the bowel is perforated, early recognition and treatment is imperative. Surgical consultation should be strongly considered for all cases and should be mandatory for more severe occurrences. Guidewire perforation may be managed with endoscopic stent placement.[223] Guidewire injuries may potentially be reduced with the use of hydrophilic tip wire, fluoroscopy, and avoidance of blind manipulation.[206],[219],[224]

  Cholangitis and Cholecystitis Top

Cholangitis and cholecystitis are rare complications associated with inadequate biliary drainage, concurrent performance of percutaneous-endoscopic procedures, stenting across malignant strictures, presence of jaundice, and low ERCP case volume.[1],[7] Post-ERCP cholangitis has a rate of occurrence of 1%–3%.[1],[7],[137],[225] There may also be an association between diagnostic versus therapeutic ERCP in terms of cholangitis risk.[25] Care should be taken when performing ERCP in cases of biliary obstruction to avoid contrast injections into undrained hepatic segments. To avoid delayed cholangitis in the setting of biliary obstruction, adequate drainage with stents or nasobiliary tubes is very important. Plastic stents can help reduce the risk of cholangitis following gallstone extraction attempts.[2] When dealing with hilar obstruction (e.g., Klatskin tumor), it is important to adequately drain all intrahepatic segments that have been filled with contrast during the procedure.[226],[227] Stent placement in the latter setting is a complex topic and is beyond the scope of this review. However, considerations regarding stent laterality, multiplicity, the incidence of obstruction or re-occlusion, and the risk of associated cholangitis must be carefully weighted.[18],[226],[227]

The incidence of post-ERCP cholecystitis is approximately 0.5%.[137] This occurrence may be associated with the intraprocedural filling of the gallbladder with contrast in the presence of gallbladder stones.[2] The presence of malignancy involving the orifice of the cystic duct has also been linked to this post-ERCP complication.[228] Diagnosis and treatment should follow established clinical guidelines for the management of cholecystitis.[229],[230],[231] Finally, it has been reported that iatrogenic intramural dissection of the gallbladder wall can mimic post-ERCP cholecystitis.[232]

  Cardiopulmonary Events Top

Although they occur in <1% of procedures, cardiopulmonary complications are the major cause of ERCP-related mortality.[1],[91],[114],[137],[233] Cardiac arrhythmia, hypoventilation, or aspiration are all possible and may be associated with either the presence of comorbid conditions or the use of intraprocedural analgosedation.[91],[233] Some degree of hypoxia may be seen in 7%–40% of cases, with aspiration occurring in approximately 0.3%–1.0% cases.[6],[234] Of note, both hypoxic events and aspiration tend to be associated with advanced age, chronic illness, neurological impairment, supine positioning, and the use of conscious sedation.[6],[234],[235],[236] Morbidity in this general area may be reduced by careful preoperative evaluation, close collaboration with the anesthesiology team, and meticulous perioperative planning for high-risk or difficult-to-sedate patients.[6],[234],[235],[236],[237],[238]

  Miscellaneous Complications Top

A wide variety of other ERCP-associated complications have been reported in the literature including ileus, antibiotic-related diarrhea, hepatic abscess formation, pneumothorax/pneumomediastinum, perforation of colonic diverticula, duodenal injury/hematoma, portal venous air, and impaction of therapeutic devices such as stone retrieval baskets.[1],[114],[239],[240] Delayed gallstone ileus has also been reported following ERCP and sphincterotomy.[241],[242],[243] Wire entrapment may contribute to wire fracture from excessive traction.[244] Guidewire fracture can also happen due to retrieval basket impaction around the ampulla.[245] The presence of irregular, hard, or multiple stones may increase the risk of impaction. Approaches to minimize this risk include fluoroscopic guidance and continuous moistening of hydrophilic wires to avoid desiccation and fracture.[246],[247]

  Conclusion Top

Despite being considered a relatively safe procedure, ERCP can be associated with a broad range of potentially severe complications. ERCP-associated pancreatitis, hemorrhage, infections, and perforations are among the most feared morbidities. Providers who perform ERCPs and/or care for patients undergoing these endoscopic procedures should be familiar with specific risk factors, accompanying signs and symptoms, and be knowledgeable regarding corresponding clinical management. Despite numerous clinical trials for pharmacological prophylaxis, currently only rectal diclofenac appears to help prevent ERCP-associated pancreatitis. Given the significant percentage of nontherapeutic ERCPs, alternative imaging modalities (e.g., CT, EUS, or MRCP) may be preferable as “screening” tests given similar diagnostic accuracy and favorable overall complication profile.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

  References Top

Loperfido S, Angelini G, Benedetti G, Chilovi F, Costan F, De Berardinis F, et al. Major early complications from diagnostic and therapeutic ERCP: A prospective multicenter study. Gastrointest Endosc 1998;48:1-10.  Back to cited text no. 1
Mallery JS, Baron TH, Dominitz JA, Goldstein JL, Hirota WK, Jacobson BC, et al. Complications of ERCP. Gastrointest Endosc 2003;57:633-8.  Back to cited text no. 2
Arguedas MR, Dupont AW, Wilcox CM. Where do ERCP, endoscopic ultrasound, magnetic resonance cholangiopancreatography, and intraoperative cholangiography fit in the management of acute biliary pancreatitis? A decision analysis model. Am J Gastroenterol 2001;96:2892-9.  Back to cited text no. 3
Shiralkar U. Smart Surgeons; Sharp Decisions: Cognitive skills to Avoid Errors & Achieve Results. TFM Publishing Limited; 2011.  Back to cited text no. 4
Parra-Membrives P, Díaz-Gómez D, Vilegas-Portero R, Molina-Linde M, Gómez-Bujedo L, Lacalle-Remigio JR, et al. Appropriate management of common bile duct stones: A RAND corporation/UCLA appropriateness method statistical analysis. Surg Endosc 2010;24:1187-94.  Back to cited text no. 5
Froehlich F, Gonvers JJ, Vader JP, Dubois RW, Burnand B. Appropriateness of gastrointestinal endoscopy: Risk of complications. Endoscopy 1999;31:684-6.  Back to cited text no. 6
Silviera ML, Seamon MJ, Porshinsky B, Prosciak MP, Doraiswamy VA, Wang CF, et al. Complications related to endoscopic retrograde cholangiopancreatography: A comprehensive clinical review. J Gastrointestin Liver Dis 2009;18:73-82.  Back to cited text no. 7
Brugge WR. Endoscopic approach to the diagnosis and treatment of pancreatic disease. Curr Opin Gastroenterol 2013;29:559-65.  Back to cited text no. 8
Brugge WR, Van Dam J. Pancreatic and biliary endoscopy. N Engl J Med 1999;341:1808-16.  Back to cited text no. 9
Draganov PV, Chauhan S, Wagh MS, Gupte AR, Lin T, Hou W, et al. Diagnostic accuracy of conventional and cholangioscopy-guided sampling of indeterminate biliary lesions at the time of ERCP: A prospective, long-term follow-up study. Gastrointest Endosc 2012;75:347-53.  Back to cited text no. 10
Eaton JE, Talwalkar JA, Lazaridis KN, Gores GJ, Lindor KD. Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management. Gastroenterology 2013;145:521-36.  Back to cited text no. 11
Mehta SN, Pavone E, Barkun JS, Bouchard S, Barkun AN. Predictors of post-ERCP complications in patients with suspected choledocholithiasis. Endoscopy 1998;30:457-63.  Back to cited text no. 12
Baron TH Sr, Davee T. Endoscopic management of benign bile duct strictures. Gastrointest Endosc Clin N Am 2013;23:295-311.  Back to cited text no. 13
Dumonceau JM, Tringali A, Blero D, Devière J, Laugiers R, Heresbach D, et al. Biliary stenting: Indications, choice of stents and results: European society of gastrointestinal endoscopy (ESGE) clinical guideline. Endoscopy 2012;44:277-98.  Back to cited text no. 14
Adler DG, Baron TH, Davila RE, Egan J, Hirota WK, Leighton JA, et al. ASGE guideline: The role of ERCP in diseases of the biliary tract and the pancreas. Gastrointest Endosc 2005;62:1-8.  Back to cited text no. 15
Hall TC, Dennison AR, Garcea G. The diagnosis and management of sphincter of oddi dysfunction: A systematic review. Langenbecks Arch Surg 2012;397:889-98.  Back to cited text no. 16
Pannala R, Petersen BT, Gostout CJ, Topazian MD, Levy MJ, Baron TH, et al. Endoscopic transpapillary gallbladder drainage: 10-year single center experience. Minerva Gastroenterol Dietol 2008;54:107-13.  Back to cited text no. 17
Ferreira LE, Baron TH. Endoscopic stenting for palliation of malignant biliary obstruction. Expert Rev Med Devices 2010;7:681-91.  Back to cited text no. 18
Kim HS, Moon JH, Choi HJ, Lee JC, Han SH, Hong SJ, et al. The role of intraductal US in the management of idiopathic recurrent pancreatitis without a definite cause on ERCP. Gastrointest Endosc 2011;73:1148-54.  Back to cited text no. 19
Nguyen NT, Hinojosa MW, Slone J, Lee J, Khiatani V, Wilson SE, et al. Laparoscopic transgastric access to the biliary tree after roux-en-Y gastric bypass. Obes Surg 2007;17:416-9.  Back to cited text no. 20
Lans JI, Geenen JE, Johanson JF, Hogan WJ. Endoscopic therapy in patients with pancreas divisum and acute pancreatitis: A prospective, randomized, controlled clinical trial. Gastrointest Endosc 1992;38:430-4.  Back to cited text no. 21
Heyries L, Barthet M, Delvasto C, Zamora C, Bernard JP, Sahel J, et al. Long-term results of endoscopic management of pancreas divisum with recurrent acute pancreatitis. Gastrointest Endosc 2002;55:376-81.  Back to cited text no. 22
Rösch T, Daniel S, Scholz M, Huibregtse K, Smits M, Schneider T, et al. Endoscopic treatment of chronic pancreatitis: A multicenter study of 1000 patients with long-term follow-up. Endoscopy 2002;34:765-71.  Back to cited text no. 23
Moon SH, Kim MH, Park DH, Song TJ, Eum J, Lee SS, et al. Modified fully covered self-expandable metal stents with antimigration features for benign pancreatic-duct strictures in advanced chronic pancreatitis, with a focus on the safety profile and reducing migration. Gastrointest Endosc 2010;72:86-91.  Back to cited text no. 24
Lal D, Lane M, Wong P. Complications of endoscopic retrograde cholangiopancreatography. N Zealand Med J (Online) 2003;116:1-5.  Back to cited text no. 25
Chennat J. Indications for endoscopic retrograde cholangiopancreatography. Techn Gastrointest Endosc 2012;14:130-4.  Back to cited text no. 26
Baron TH. Endoscopic retrograde cholangiopancreatography for cholangiocarcinoma. Clin Liver Dis 2014;18:891-7.  Back to cited text no. 27
Cotton PB, Vallon AG. British experience with duodenoscopic sphincterotomy for removal of bile duct stones. Br J Surg 1981;68:373-5.  Back to cited text no. 28
Rosseland AR, Solhaug JH. Early or delayed endoscopic papillotomy (EPT) in gallstone pancreatitis. Ann Surg 1984;199:165-7.  Back to cited text no. 29
Clarke GA, Jacobson BC, Hammett RJ, Carr-Locke DL. The indications, utilization and safety of gastrointestinal endoscopy in an extremely elderly patient cohort. Endoscopy 2001;33:580-4.  Back to cited text no. 30
Lin LF, Siauw CP, Ho KS, Tung JC. ERCP in post-billroth II gastrectomy patients: Emphasis on technique. Am J Gastroenterol 1999;94:144-8.  Back to cited text no. 31
Goumas K, Poulou A. Endoscopic Retrograde Cholangiopancreatography, in Liver and Biliary Tract Surgery. Springer; 2006. p. 87-109.  Back to cited text no. 32
Frey CF, et al. Endoscopic retrograde cholangiopancreatography. Am J Surg 1982;144:109-14.  Back to cited text no. 33
Romagnuolo J, Bardou M, Rahme E, Joseph L, Reinhold C, Barkun AN, et al. Magnetic resonance cholangiopancreatography: A meta-analysis of test performance in suspected biliary disease. Ann Intern Med 2003;139:547-57.  Back to cited text no. 34
Hekimoglu K, Ustundag Y, Dusak A, Erdem Z, Karademir B, Aydemir S, et al. MRCP vs. ERCP in the evaluation of biliary pathologies: Review of current literature. J Dig Dis 2008;9:162-9.  Back to cited text no. 35
Mandelia A, Gupta AK, Verma DK, Sharma S. The value of magnetic resonance cholangio-pancreatography (MRCP) in the detection of choledocholithiasis. J Clin Diagn Res 2013;7:1941-5.  Back to cited text no. 36
Hjartarson JH, Hannesson P, Sverrisson I, Blöndal S, Ívarsson B, Björnsson ES, et al. The value of magnetic resonance cholangiopancreatography for the exclusion of choledocholithiasis. Scand J Gastroenterol 2016;51:1249-56.  Back to cited text no. 37
Cavdar F, Yildar M, Tellioğlu G, Kara M, Tilki M, Titiz Mİ, et al. Controversial issues in biliary pancreatitis: When should we perform MRCP and ERCP? Pancreatology 2014;14:411-4.  Back to cited text no. 38
Watanabe Y, Nagayama M, Okumura A, Amoh Y, Katsube T, Suga T, et al. MR imaging of acute biliary disorders. Radiographics 2007;27:477-95.  Back to cited text no. 39
Glockner JF. Hepatobiliary MRI: Current concepts and controversies. J Magn Reson Imaging 2007;25:681-95.  Back to cited text no. 40
Hoeffel C, Azizi L, Lewin M, Laurent V, Aubé C, Arrivé L, et al. Normal and pathologic features of the postoperative biliary tract at 3D MR cholangiopancreatography and MR imaging. Radiographics 2006;26:1603-20.  Back to cited text no. 41
Balci NC, Alkaade S, Magas L, Momtahen AJ, Burton FR. Suspected chronic pancreatitis with normal MRCP: Findings on MRI in correlation with secretin MRCP. J Magn Reson Imaging 2008;27:125-31.  Back to cited text no. 42
Kaltenthaler EC, Walters SJ, Chilcott J, Blakeborough A, Vergel YB, Thomas S, et al. MRCP compared to diagnostic ERCP for diagnosis when biliary obstruction is suspected: A systematic review. BMC Med Imaging 2006;6:9.  Back to cited text no. 43
Forbes A, Cotton PB. ERCP and sphincterotomy after billroth II gastrectomy. Gut 1984;25:971-4.  Back to cited text no. 44
Soto JA, Yucel EK, Barish MA, Chuttani R, Ferrucci JT. MR cholangiopancreatography after unsuccessful or incomplete ERCP. Radiology 1996;199:91-8.  Back to cited text no. 45
Pavone P, Laghl A, Catalano C, Broglia L, Messina A, Passariello R. 3-dimensional mr cholangiography-a unique diagnostic procedure for evaluation of bile-ducts in patients with biliary-enteric anastomosis. In: Radiology. 1995; 197:312-312.  Back to cited text no. 46
Barish MA, Yucel EK, Ferrucci JT. Magnetic resonance cholangiopancreatography. N Engl J Med 1999;341:258-64.  Back to cited text no. 47
Mandarano G, Sim J. The diagnostic MRCP examination: Overcoming technical challenges to ensure clinical success. Biomed Imaging Interv J 2008;4:e28.  Back to cited text no. 48
David V, Reinhold C, Hochman M, Chuttani R, McKee J, Waxman I, et al. Pitfalls in the interpretation of MR cholangiopancreatography. AJR Am J Roentgenol 1998;170:1055-9.  Back to cited text no. 49
Fagenholz PJ, Fernández-del Castillo C, Harris NS, Pelletier AJ, Camargo CA Jr. Direct medical costs of acute pancreatitis hospitalizations in the United States. Pancreas 2007;35:302-7.  Back to cited text no. 50
Cowper SE. Nephrogenic systemic fibrosis: A review and exploration of the role of gadolinium. Adv Dermatol 2007;23:131-54.  Back to cited text no. 51
Murphy KJ, Brunberg JA. Adult claustrophobia, anxiety and sedation in MRI. Magn Reson Imaging 1997;15:51-4.  Back to cited text no. 52
Phillips EH. Controversies in the management of common duct calculi. Surg Clin North Am 1994;74:931-48.  Back to cited text no. 53
Yeh BM, Liu PS, Soto JA, Corvera CA, Hussain HK. MR imaging and CT of the biliary tract. Radiographics 2009;29:1669-88.  Back to cited text no. 54
Radiology, A.C.O. ACR Manual on Contrast Media; 2015. https://www.acr.org/Clinical-Resources/Contrast-Manual. [Last accessed on 2018 Aug 06].  Back to cited text no. 55
Mallery S, Matlock J, Freeman ML. EUS-guided rendezvous drainage of obstructed biliary and pancreatic ducts: Report of 6 cases. Gastrointest Endosc 2004;59:100-7.  Back to cited text no. 56
Soto JA, Alvarez O, Múnera F, Velez SM, Valencia J, Ramírez N, et al. Diagnosing bile duct stones: Comparison of unenhanced helical CT, oral contrast-enhanced CT cholangiography, and MR cholangiography. AJR Am J Roentgenol 2000;175:1127-34.  Back to cited text no. 57
Maher MM, Kalra MK, Sahani DV, Perumpillichira JJ, Rizzo S, Saini S, et al. Techniques, clinical applications and limitations of 3D reconstruction in CT of the abdomen. Korean J Radiol 2004;5:55-67.  Back to cited text no. 58
Mueller PR, van Sonnenberg E, Ferrucci JT Jr. Percutaneous biliary drainage: Technical and catheter-related problems in 200 procedures. AJR Am J Roentgenol 1982;138:17-23.  Back to cited text no. 59
Ferrucci JT Jr., Mueller PR, Harbin WP. Percutaneous transhepatic biliary drainage: Technique, results, and applications. Radiology 1980;135:1-3.  Back to cited text no. 60
Clouse ME, Stokes KR, Lee RG, Falchuk KR. Bile duct stones: Percutaneous transhepatic removal. Radiology 1986;160:525-9.  Back to cited text no. 61
Ang TL, Teo EK, Fock KM. Endosonography- vs. endoscopic retrograde cholangiopancreatography-based strategies in the evaluation of suspected common bile duct stones in patients with normal transabdominal imaging. Aliment Pharmacol Ther 2007;26:1163-70.  Back to cited text no. 62
Tse F, Liu L, Barkun AN, Armstrong D, Moayyedi P. EUS: A meta-analysis of test performance in suspected choledocholithiasis. Gastrointest Endosc 2008;67:235-44.  Back to cited text no. 63
Rösch T, Hofrichter K, Frimberger E, Meining A, Born P, Weigert N, et al. ERCP or EUS for tissue diagnosis of biliary strictures? A prospective comparative study. Gastrointest Endosc 2004;60:390-6.  Back to cited text no. 64
Gupta K, Mallery S, Hunter D, Freeman ML. Endoscopic ultrasound and percutaneous access for endoscopic biliary and pancreatic drainage after initially failed ERCP. Rev Gastroenterol Disord 2007;7:22-37.  Back to cited text no. 65
Ross WA, Wasan SM, Evans DB, Wolff RA, Trapani LV, Staerkel GA, et al. Combined EUS with FNA and ERCP for the evaluation of patients with obstructive jaundice from presumed pancreatic malignancy. Gastrointest Endosc 2008;68:461-6.  Back to cited text no. 66
Tse F, Barkun JS, Barkun AN. The elective evaluation of patients with suspected choledocholithiasis undergoing laparoscopic cholecystectomy. Gastrointest Endosc 2004;60:437-48.  Back to cited text no. 67
Yang MH, Chen TH, Wang SE, Tsai YF, Su CH, Wu CW, et al. Biochemical predictors for absence of common bile duct stones in patients undergoing laparoscopic cholecystectomy. Surg Endosc 2008;22:1620-4.  Back to cited text no. 68
Barkun AN, Barkun JS, Fried GM, Ghitulescu G, Steinmetz O, Pham C, et al. Useful predictors of bile duct stones in patients undergoing laparoscopic cholecystectomy. McGill gallstone treatment group. Ann Surg 1994;220:32-9.  Back to cited text no. 69
Onken JE, Brazer SR, Eisen GM, Williams DM, Bouras EP, DeLong ER, et al. Predicting the presence of choledocholithiasis in patients with symptomatic cholelithiasis. Am J Gastroenterol 1996;91:762-7.  Back to cited text no. 70
Liu TH, Consorti ET, Kawashima A, Tamm EP, Kwong KL, Gill BS, et al. Patient evaluation and management with selective use of magnetic resonance cholangiography and endoscopic retrograde cholangiopancreatography before laparoscopic cholecystectomy. Ann Surg 2001;234:33-40.  Back to cited text no. 71
Prat F, Meduri B, Ducot B, Chiche R, Salimbeni-Bartolini R, Pelletier G, et al. Prediction of common bile duct stones by noninvasive tests. Ann Surg 1999;229:362-8.  Back to cited text no. 72
Chen MY, Van Swearingen FL, Mitchell R, Ott DJ. Radiation exposure during ERCP: Effect of a protective shield. Gastrointest Endosc 1996;43:1-5.  Back to cited text no. 73
Miller LR. Endoscopic stent placement; a nursing perspective. Gastroenterol Nurs 1984;7:17-20.  Back to cited text no. 74
Orenstein SB, Marks JM, Hardacre JM. Technical aspects of bile duct evaluation and exploration. Surg Clin North Am 2014;94:281-96.  Back to cited text no. 75
Vennes JA, Silvis SE. Endoscopic visualization of bile and pancreatic ducts. Gastrointest Endosc 1972;18:149-52.  Back to cited text no. 76
ASGE Training Committee, Jorgensen J, Kubiliun N, Law JK, Al-Haddad MA, Bingener-Casey J, et al. Endoscopic retrograde cholangiopancreatography (ERCP): Core curriculum. Gastrointest Endosc 2016;83:279-89.  Back to cited text no. 77
Lee A, Lee LS. Training in Endoscopic Retrograde Cholangiopancreatography, in ERCP and EUS. New York, NY: Springer; 2015. p. 3-18.  Back to cited text no. 78
Cotton PB, Williams CB. Practical Gastrointestinal Endoscopy: The Fundamentals. Somerset, NJ: John Wiley & Sons; 2008.  Back to cited text no. 79
Naji AF. Detection of Hepatobiliary Diseases using Magnetic Resonance Cholangiopancreatography (MRCP). Sudan University of Science and Technology; 2014.  Back to cited text no. 80
Zeleňák K, Števík M. Radiology of acute pancreatitis and its complications. In: Acute Pancreatitis. Hauppauge, NY; NOVA Science Publishers. p. 143.  Back to cited text no. 81
Schrag SP, Sharma R, Jaik NP, Seamon MJ, Lukaszczyk JJ, Martin ND, et al. Complications related to percutaneous endoscopic gastrostomy (PEG) tubes. A comprehensive clinical review. J Gastrointestin Liver Dis 2007;16:407-18.  Back to cited text no. 82
Harris A, Chan AC, Torres-Viera C, Hammett R, Carr-Locke D. Meta-analysis of antibiotic prophylaxis in endoscopic retrograde cholangiopancreatography (ERCP). Endoscopy 1999;31:718-24.  Back to cited text no. 83
Niederau C, Pohlmann U, Lübke H, Thomas L. Prophylactic antibiotic treatment in therapeutic or complicated diagnostic ERCP: Results of a randomized controlled clinical study. Gastrointest Endosc 1994;40:533-7.  Back to cited text no. 84
Hirota WK, Petersen K, Baron TH, Goldstein JL, Jacobson BC, Leighton JA, et al. Guidelines for antibiotic prophylaxis for GI endoscopy. Gastrointest Endosc 2003;58:475-82.  Back to cited text no. 85
Cotton PB, Connor P, Rawls E, Romagnuolo J. Infection after ERCP, and antibiotic prophylaxis: A sequential quality-improvement approach over 11 years. Gastrointest Endosc 2008;67:471-5.  Back to cited text no. 86
Allison MC, Sandoe JA, Tighe R, Simpson IA, Hall RJ, Elliott TS, et al. Antibiotic prophylaxis in gastrointestinal endoscopy. Gut 2009;58:869-80.  Back to cited text no. 87
Ceyssens C, Frans JM, Christiaens PS, Van Steenbergen W, Peetermans WE. Recommendations for antibiotic prophylaxis before ERCP: Can we come to workable conclusions after review of the literature? Acta Clin Belg 2006;61:10-8.  Back to cited text no. 88
Ogilvie J, Hicks LM, Kalloo A. Johns Hopkins Manual of Gastrointestinal Endoscopic Procedures. SLACK Incorporated; 2008.  Back to cited text no. 89
Kataria H, Sharma R, Bansiwal R, Jindal A, Attri AK. Endoscopic needle knife sphincterotome-an alternative for retrieval of an entrapped nasogastric tube. Indian J Surg 2015;77:1473-5.  Back to cited text no. 90
Rotondano G. Reducing complications in upper gastrointestinal endoscopy. Expert Rev Gastroenterol Hepatol 2012;6:271-90.  Back to cited text no. 91
Leung J. Fundamentals of ERCP. Advanced Digestive Endoscopy: ERCP. Hoboken, NJ: Blackwell Science; 2005. p. 17-80.  Back to cited text no. 92
Baillie J. ERCP from Soup to Nuts: Evaluation, Preparation, Execution, and Follow-Up, in ERCP and EUS. New York, NY: Springer: 2015. p. 57-76.  Back to cited text no. 93
Leung J. Standard Devices and Techniques. ERCP: The Fundamentals; 2014. p. 69.  Back to cited text no. 94
Roberts DN, Maple JT. The role of endoscopic ultrasonography (EUS) and endoscopic retrograde cholangiography (ERC) in diagnosing choledocholithiasis. Techn Gastrointest Endosc 2009;11:2-12.  Back to cited text no. 95
Kim TK, Kim BS, Kim JH, Ha HK, Kim PN, Kim AY, et al. Diagnosis of intrahepatic stones: Superiority of MR cholangiopancreatography over endoscopic retrograde cholangiopancreatography. AJR Am J Roentgenol 2002;179:429-34.  Back to cited text no. 96
Hicken NF, Mcallister AJ, Walker G. The problem of retained common duct stones. Am J Surg 1959;97:173-82.  Back to cited text no. 97
Artifon EL, Sakai P, Cunha JE, Halwan B, Ishioka S, Kumar A, et al. Guidewire cannulation reduces risk of post-ERCP pancreatitis and facilitates bile duct cannulation. Am J Gastroenterol 2007;102:2147-53.  Back to cited text no. 98
Park JS, Jeong S, Lee DH. Recent advances in gastrointestinal stent development. Clin Endosc 2015;48:209-15.  Back to cited text no. 99
Shah TU, Keilin S. Palliative Care for Patients with Advanced Gastrointestinal Malignancies. Gastrointestinal Malignancies: New Innovative Diagnostics and Treatment. Vol. 22. Hackensack, NJ: World Scientific; 2015. p. 141.  Back to cited text no. 100
Wright ER, Bakis G, Srinivasan R, Raju R, Vittal H, Sanders MK, et al. Intraprocedural tissue diagnosis during ERCP employing a new cytology preparation of forceps biopsy (Smash protocol). Am J Gastroenterol 2011;106:294-9.  Back to cited text no. 101
Cohen J. The impact of tissue sampling on endoscopy efficiency. Gastrointest Endosc Clin N Am 2004;14:725-34, x.  Back to cited text no. 102
Weaver GW. Multi-Lumen Endoscopic Catheter. Google Patents; 2004.  Back to cited text no. 103
Williams ED, Draganov PV. Endoscopic management of biliary strictures after liver transplantation. World J Gastroenterol 2009;15:3725-33.  Back to cited text no. 104
Yoo KS, Lehman GA. Endoscopic management of biliary ductal stones. Gastroenterol Clin North Am 2010;39:209-27, viii.  Back to cited text no. 105
Trikudanathan G, Arain MA, Attam R, Freeman ML. Advances in the endoscopic management of common bile duct stones. Nat Rev Gastroenterol Hepatol 2014;11:535-44.  Back to cited text no. 106
Shim CS. How should biliary stones be managed? Gut Liver 2010;4:161-72.  Back to cited text no. 107
Moon JH, Cho YD, Cha SW, Cheon YK, Ahn HC, Kim YS, et al. The detection of bile duct stones in suspected biliary pancreatitis: Comparison of MRCP, ERCP, and intraductal US. Am J Gastroenterol 2005;100:1051-7.  Back to cited text no. 108
Das A, Isenberg G, Wong RC, Sivak MV Jr., Chak A. Wire-guided intraductal US: An adjunct to ERCP in the management of bile duct stones. Gastrointest Endosc 2001;54:31-6.  Back to cited text no. 109
Cushing GL, Fitzgerald PJ, Bommer WJ, Andrews MW, Cronan MS, Martinez-Torres GG, et al. Intraluminal ultrasonography during ERCP with high-frequency ultrasound catheters. Gastrointest Endosc 1993;39:432-5.  Back to cited text no. 110
Morino M, Arezzo A. Cholecystocholedocholithiasis: Two-Stage Treatment. In: Biliary Lithiasis. Milan, Italy: Springer; 2008. p. 325-39.  Back to cited text no. 111
Laasch HU, Tringali A, Wilbraham L, Marriott A, England RE, Mutignani M, et al. Comparison of standard and steerable catheters for bile duct cannulation in ERCP. Endoscopy 2003;35:669-74.  Back to cited text no. 112
Davee T, Garcia JA, Baron TH. Precut sphincterotomy for selective biliary duct cannulation during endoscopic retrograde cholangiopancreatography. Ann Gastroenterol 2012;25:291-302.  Back to cited text no. 113
Masci E, Toti G, Mariani A, Curioni S, Lomazzi A, Dinelli M, et al. Complications of diagnostic and therapeutic ERCP: A prospective multicenter study. Am J Gastroenterol 2001;96:417-23.  Back to cited text no. 114
Balmadrid B, Kozarek R. Prevention and management of adverse events of endoscopic retrograde cholangiopancreatography. Gastrointest Endosc Clin N Am 2013;23:385-403.  Back to cited text no. 115
Rabenstein T, Hahn EG. Post-ERCP pancreatitis: Is the endoscopist's experience the major risk factor? JOP 2002;3:177-87.  Back to cited text no. 116
Andriulli A, Loperfido S, Napolitano G, Niro G, Valvano MR, Spirito F, et al. Incidence rates of post-ERCP complications: A systematic survey of prospective studies. Am J Gastroenterol 2007;102:1781-8.  Back to cited text no. 117
Wang P, Li ZS, Liu F, Ren X, Lu NH, Fan ZN, et al. Risk factors for ERCP-related complications: A prospective multicenter study. Am J Gastroenterol 2009;104:31-40.  Back to cited text no. 118
Freeman ML, DiSario JA, Nelson DB, Fennerty MB, Lee JG, Bjorkman DJ, et al. Risk factors for post-ERCP pancreatitis: A prospective, multicenter study. Gastrointest Endosc 2001;54:425-34.  Back to cited text no. 119
Freeman ML. Adverse outcomes of endoscopic retrograde cholangiopancreatography: Avoidance and management. Gastrointest Endosc Clin N Am 2003;13:775-98, xi.  Back to cited text no. 120
Cotton PB, Garrow DA, Gallagher J, Romagnuolo J. Risk factors for complications after ERCP: A multivariate analysis of 11,497 procedures over 12 years. Gastrointest Endosc 2009;70:80-8.  Back to cited text no. 121
Trap R, Adamsen S, Hart-Hansen O, Henriksen M. Severe and fatal complications after diagnostic and therapeutic ERCP: A prospective series of claims to insurance covering public hospitals. Endoscopy 1999;31:125-30.  Back to cited text no. 122
Szary NM, Al-Kawas FH. Complications of endoscopic retrograde cholangiopancreatography: How to avoid and manage them. Gastroenterol Hepatol (N Y) 2013;9:496-504.  Back to cited text no. 123
Lella F, Bagnolo F, Colombo E, Bonassi U. A simple way of avoiding post-ERCP pancreatitis. Gastrointest Endosc 2004;59:830-4.  Back to cited text no. 124
Thaker AM, Mosko JD, Berzin TM. Post-endoscopic retrograde cholangiopancreatography pancreatitis. Gastroenterol Rep (Oxf) 2015;3:32-40.  Back to cited text no. 125
Costamagna G, Mutignani M, Ingrosso M, Vamvakousis V, Alevras P, Manta R, et al. Endoscopic treatment of postsurgical external pancreatic fistulas. Endoscopy 2001;33:317-22.  Back to cited text no. 126
Freeman ML, Guda NM. Prevention of post-ERCP pancreatitis: A comprehensive review. Gastrointest Endosc 2004;59:845-64.  Back to cited text no. 127
Sherman S, Lehman GA. ERCP- and endoscopic sphincterotomy-induced pancreatitis. Pancreas 1991;6:350-67.  Back to cited text no. 128
Gottlieb K, Sherman S. ERCP and biliary endoscopic sphincterotomy-induced pancreatitis. Gastrointest Endosc Clin N Am 1998;8:87-114.  Back to cited text no. 129
Arata S, Takada T, Hirata K, Yoshida M, Mayumi T, Hirota M, et al. Post-ERCP pancreatitis. J Hepatobiliary Pancreat Sci 2010;17:70-8.  Back to cited text no. 130
Bracher GA, Manocha AP, DeBanto JR, Gates LK Jr., Slivka A, Whitcomb DC, et al. Endoscopic pancreatic duct stenting to treat pancreatic ascites. Gastrointest Endosc 1999;49:710-5.  Back to cited text no. 131
Cheng CL, Sherman S, Watkins JL, Barnett J, Freeman M, Geenen J, et al. Risk factors for post-ERCP pancreatitis: A prospective multicenter study. Am J Gastroenterol 2006;101:139-47.  Back to cited text no. 132
Cotton PB, Lehman G, Vennes J, Geenen JE, Russell RC, Meyers WC, et al. Endoscopic sphincterotomy complications and their management: An attempt at consensus. Gastrointest Endosc 1991;37:383-93.  Back to cited text no. 133
Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, et al. Classification of acute pancreatitis–2012: Revision of the atlanta classification and definitions by international consensus. Gut 2013;62:102-11.  Back to cited text no. 134
Guda NM, Reddy DN, Kumar A. Complications of ERCP. Indian J Gastroenterol 2014;33:1-9.  Back to cited text no. 135
Testoni PA, Mariani A, Giussani A, Vailati C, Masci E, Macarri G, et al. Risk factors for post-ERCP pancreatitis in high- and low-volume centers and among expert and non-expert operators: A prospective multicenter study. Am J Gastroenterol 2010;105:1753-61.  Back to cited text no. 136
Freeman ML, Nelson DB, Sherman S, Haber GB, Herman ME, Dorsher PJ, et al. Complications of endoscopic biliary sphincterotomy. N Engl J Med 1996;335:909-18.  Back to cited text no. 137
Kapral C, Duller C, Wewalka F, Kerstan E, Vogel W, Schreiber F, et al. Case volume and outcome of endoscopic retrograde cholangiopancreatography: Results of a nationwide austrian benchmarking project. Endoscopy 2008;40:625-30.  Back to cited text no. 138
Cotton PB. Cannulation of the papilla of vater by endoscopy and retrograde cholangiopancreatography (ERCP). Gut 1972;13:1014-25.  Back to cited text no. 139
Vandervoort J, Soetikno RM, Tham TC, Wong RC, Ferrari AP Jr., Montes H, et al. Risk factors for complications after performance of ERCP. Gastrointest Endosc 2002;56:652-6.  Back to cited text no. 140
Patel R. Does stenting after pancreatic sphincterotomy reduce post-ERCP pancreatitis in patients with prior biliary sphincterotomy? Preliminary results of a prospective randomized trial. Gastrointest Endosc 1999;49 (4 Pt 2):AB80.  Back to cited text no. 141
Cheon YK, Cho KB, Watkins JL, McHenry L, Fogel EL, Sherman S, et al. Frequency and severity of post-ERCP pancreatitis correlated with extent of pancreatic ductal opacification. Gastrointest Endosc 2007;65:385-93.  Back to cited text no. 142
Vandervoort J, Soetikno RM, Montes H, Lichtenstein DR, Van Dam J, Ruymann FW, et al. Accuracy and complication rate of brush cytology from bile duct versus pancreatic duct. Gastrointest Endosc 1999;49:322-7.  Back to cited text no. 143
Disario JA, Freeman ML, Bjorkman DJ, Macmathuna P, Petersen BT, Jaffe PE, et al. Endoscopic balloon dilation compared with sphincterotomy for extraction of bile duct stones. Gastroenterology 2004;127:1291-9.  Back to cited text no. 144
Masci E, Mariani A, Curioni S, Testoni PA. Risk factors for pancreatitis following endoscopic retrograde cholangiopancreatography: A meta-analysis. Endoscopy 2003;35:830-4.  Back to cited text no. 145
Dumonceau JM, Andriulli A, Deviere J, Mariani A, Rigaux J, Baron TH, et al. European society of gastrointestinal endoscopy (ESGE) guideline: Prophylaxis of post-ERCP pancreatitis. Endoscopy 2010;42:503-15.  Back to cited text no. 146
Testoni PA, Testoni S, Giussani A. Difficult biliary cannulation during ERCP: How to facilitate biliary access and minimize the risk of post-ERCP pancreatitis. Dig Liver Dis 2011;43:596-603.  Back to cited text no. 147
Harewood GC, Baron TH. An assessment of the learning curve for precut biliary sphincterotomy. Am J Gastroenterol 2002;97:1708-12.  Back to cited text no. 148
Elta GH, Barnett JL, Wille RT, Brown KA, Chey WD, Scheiman JM, et al. Pure cut electrocautery current for sphincterotomy causes less post-procedure pancreatitis than blended current. Gastrointest Endosc 1998;47:149-53.  Back to cited text no. 149
Siegel JH, Veerappan A, Tucker R. Bipolar versus monopolar sphincterotomy: A prospective trial. Am J Gastroenterol 1994;89:1827-30.  Back to cited text no. 150
Fogel EL, Eversman D, Jamidar P, Sherman S, Lehman GA. Sphincter of oddi dysfunction: Pancreaticobiliary sphincterotomy with pancreatic stent placement has a lower rate of pancreatitis than biliary sphincterotomy alone. Endoscopy 2002;34:280-5.  Back to cited text no. 151
Tarnasky PR, Palesch YY, Cunningham JT, Mauldin PD, Cotton PB, Hawes RH, et al. Pancreatic stenting prevents pancreatitis after biliary sphincterotomy in patients with sphincter of oddi dysfunction. Gastroenterology 1998;115:1518-24.  Back to cited text no. 152
Sherman S, Troiano FP, Hawes RH, Lehman GA. Sphincter of oddi manometry: Decreased risk of clinical pancreatitis with use of a modified aspirating catheter. Gastrointest Endosc 1990;36:462-6.  Back to cited text no. 153
Wehrmann T, Stergiou N, Schmitt T, Dietrich CF, Seifert H. Reduced risk for pancreatitis after endoscopic microtransducer manometry of the sphincter of Oddi: A randomized comparison with the perfusion manometry technique. Endoscopy 2003;35:472-7.  Back to cited text no. 154
Choudhary A, Bechtold ML, Arif M, Szary NM, Puli SR, Othman MO, et al. Pancreatic stents for prophylaxis against post-ERCP pancreatitis: A meta-analysis and systematic review. Gastrointest Endosc 2011;73:275-82.  Back to cited text no. 155
Freeman ML. Pancreatic stents for prevention of post-ERCP pancreatitis: For everyday practice or for experts only? Gastrointest Endosc 2010;71:940-4.  Back to cited text no. 156
Sofuni A, Maguchi H, Mukai T, Kawakami H, Irisawa A, Kubota K, et al. Endoscopic pancreatic duct stents reduce the incidence of post-endoscopic retrograde cholangiopancreatography pancreatitis in high-risk patients. Clin Gastroenterol Hepatol 2011;9:851-8.  Back to cited text no. 157
Freeman ML, Overby C, Qi D. Pancreatic stent insertion: Consequences of failure and results of a modified technique to maximize success. Gastrointest Endosc 2004;59:8-14.  Back to cited text no. 158
Bakman YG, Safdar K, Freeman ML. Significant clinical implications of prophylactic pancreatic stent placement in previously normal pancreatic ducts. Endoscopy 2009;41:1095-8.  Back to cited text no. 159
Kozarek RA. Pancreatic stents can induce ductal changes consistent with chronic pancreatitis. Gastrointest Endosc 1990;36:93-5.  Back to cited text no. 160
Smith MT, Sherman S, Ikenberry SO, Hawes RH, Lehman GA. Alterations in pancreatic ductal morphology following polyethylene pancreatic stent therapy. Gastrointest Endosc 1996;44:268-75.  Back to cited text no. 161
Brackbill S, Young S, Schoenfeld P, Elta G. A survey of physician practices on prophylactic pancreatic stents. Gastrointest Endosc 2006;64:45-52.  Back to cited text no. 162
Rashdan A, Fogel EL, McHenry L Jr., Sherman S, Temkit M, Lehman GA, et al. Improved stent characteristics for prophylaxis of post-ERCP pancreatitis. Clin Gastroenterol Hepatol 2004;2:322-9.  Back to cited text no. 163
Chahal P, Tarnasky PR, Petersen BT, Topazian MD, Levy MJ, Gostout CJ, et al. Short 5Fr vs. long 3Fr pancreatic stents in patients at risk for post-endoscopic retrograde cholangiopancreatography pancreatitis. Clin Gastroenterol Hepatol 2009;7:834-9.  Back to cited text no. 164
Pahk A, Rigaux J, Poreddy V, Smith J, Al-Kawas F. Prophylactic pancreatic stents: Does size matter? A comparison of 4-fr and 5-fr stents in reference to post-ERCP pancreatitis and migration rate. Dig Dis Sci 2011;56:3058-64.  Back to cited text no. 165
Lahoti S, Catalano MF, Geenen JE, Schmalz MJ. Endoscopic retrieval of proximally migrated biliary and pancreatic stents: Experience of a large referral center. Gastrointest Endosc 1998;47:486-91.  Back to cited text no. 166
Price LH, Brandabur JJ, Kozarek RA, Gluck M, Traverso WL, Irani S, et al. Good stents gone bad: Endoscopic treatment of proximally migrated pancreatic duct stents. Gastrointest Endosc 2009;70:174-9.  Back to cited text no. 167
Chen YK, Parsi MA, Binmoeller KF, Hawes RH, Pleskow DK, Slivka A, et al. Single-operator cholangioscopy in patients requiring evaluation of bile duct disease or therapy of biliary stones (with videos). Gastrointest Endosc 2011;74:805-14.  Back to cited text no. 168
Bergman JJ, Rauws EA, Fockens P, van Berkel AM, Bossuyt PM, Tijssen JG, et al. Randomised trial of endoscopic balloon dilation versus endoscopic sphincterotomy for removal of bileduct stones. Lancet 1997;349:1124-9.  Back to cited text no. 169
Ochi Y, Mukawa K, Kiyosawa K, Akamatsu T. Comparing the treatment outcomes of endoscopic papillary dilation and endoscopic sphincterotomy for removal of bile duct stones. J Gastroenterol Hepatol 1999;14:90-6.  Back to cited text no. 170
Kubiliun NM, Elmunzer BJ. Preventing pancreatitis after endoscopic retrograde cholangiopancreatography. Gastrointest Endosc Clin N Am 2013;23:769-86.  Back to cited text no. 171
Elmunzer BJ. Preventing postendoscopic retrograde cholangiopancreatography pancreatitis. Gastrointest Endosc Clin N Am 2015;25:725-36.  Back to cited text no. 172
Badalov N, Tenner S, Baillie J. The prevention, recognition and treatment of post-ERCP pancreatitis. JOP 2009;10:88-97.  Back to cited text no. 173
Testoni P. Endoscopic papillo-sphincterotomy. Italian J Gastroenterol 1988;20:70-3.  Back to cited text no. 174
Binmoeller KF, Harris AG, Dumas R, Grimaldi C, Delmont JP. Does the somatostatin analogue octreotide protect against ERCP induced pancreatitis? Gut 1992;33:1129-33.  Back to cited text no. 175
Andriulli A, Leandro G, Federici T, Ippolito A, Forlano R, Iacobellis A, et al. Prophylactic administration of somatostatin or gabexate does not prevent pancreatitis after ERCP: An updated meta-analysis. Gastrointest Endosc 2007;65:624-32.  Back to cited text no. 176
Cavallini G, Tittobello A, Frulloni L, Masci E, Mariana A, Di Francesco V, et al. Gabexate for the prevention of pancreatic damage related to endoscopic retrograde cholangiopancreatography. Gabexate in digestive endoscopy – Italian group. N Engl J Med 1996;335:919-23.  Back to cited text no. 177
Andriulli A, Clemente R, Solmi L, Terruzzi V, Suriani R, Sigillito A, et al. Gabexate or somatostatin administration before ERCP in patients at high risk for post-ERCP pancreatitis: A multicenter, placebo-controlled, randomized clinical trial. Gastrointest Endosc 2002;56:488-95.  Back to cited text no. 178
Sherman S, Hawes RH, Rathgaber SW, Uzer MF, Smith MT, Khusro QE, et al. Post-ERCP pancreatitis: Randomized, prospective study comparing a low- and high-osmolality contrast agent. Gastrointest Endosc 1994;40:422-7.  Back to cited text no. 179
Johnson GK, Geenen JE, Bedford RA, Johanson J, Cass O, Sherman S, et al. A comparison of nonionic versus ionic contrast media: Results of a prospective, multicenter study. Midwest pancreaticobiliary study group. Gastrointest Endosc 1995;42:312-6.  Back to cited text no. 180
De Palma GD, Catanzano C. Use of corticosteroids in the prevention of post-ERCP pancreatitis: Results of a controlled prospective study. Am J Gastroenterol 1999;94:982-5.  Back to cited text no. 181
Prat F, Amaris J, Ducot B, Bocquentin M, Fritsch J, Choury AD, et al. Nifedipine for prevention of post-ERCP pancreatitis: A prospective, double-blind randomized study. Gastrointest Endosc 2002;56:202-8.  Back to cited text no. 182
Budzyńska A, Marek T, Nowak A, Kaczor R, Nowakowska-Dulawa E. A prospective, randomized, placebo-controlled trial of prednisone and allopurinol in the prevention of ERCP-induced pancreatitis. Endoscopy 2001;33:766-72.  Back to cited text no. 183
Devière J, Le Moine O, Van Laethem JL, Eisendrath P, Ghilain A, Severs N, et al. Interleukin 10 reduces the incidence of pancreatitis after therapeutic endoscopic retrograde cholangiopancreatography. Gastroenterology 2001;120:498-505.  Back to cited text no. 184
Dumot JA, Conwell DL, Zuccaro G Jr. Vargo JJ, Shay SS, Easley KA, et al. A randomized, double blind study of interleukin 10 for the prevention of ERCP-induced pancreatitis. Am J Gastroenterol 2001;96:2098-102.  Back to cited text no. 185
Rabenstein T, Roggenbuck S, Framke B, Martus P, Fischer B, Nusko G, et al. Complications of endoscopic sphincterotomy: Can heparin prevent acute pancreatitis after ERCP? Gastrointest Endosc 2002;55:476-83.  Back to cited text no. 186
Sudhindran S, Bromwich E, Edwards PR. Prospective randomized double-blind placebo-controlled trial of glyceryl trinitrate in endoscopic retrograde cholangiopancreatography-induced pancreatitis. Br J Surg 2001;88:1178-82.  Back to cited text no. 187
Moretó M, Zaballa M, Casado I, Merino O, Rueda M, Ramírez K, et al. Transdermal glyceryl trinitrate for prevention of post-ERCP pancreatitis: A randomized double-blind trial. Gastrointest Endosc 2003;57:1-7.  Back to cited text no. 188
Cheon YK, Cho KB, Watkins JL, McHenry L, Fogel EL, Sherman S, et al. Efficacy of diclofenac in the prevention of post-ERCP pancreatitis in predominantly high-risk patients: A randomized double-blind prospective trial. Gastrointest Endosc 2007;66:1126-32.  Back to cited text no. 189
Van Way CW 3rd. Surgical Intensive Care Considerations. In: Nutrition Support for the Critically Ill. Cham, Switzerland: Springer; 2016. p. 121-40.  Back to cited text no. 190
Eckerwall G, Olin H, Andersson B, Andersson R. Fluid resuscitation and nutritional support during severe acute pancreatitis in the past: What have we learned and how can we do better? Clin Nutr 2006;25:497-504.  Back to cited text no. 191
Kerdsirichairat T, Attam R, Arain M, Bakman Y, Radosevich D, Freeman M, et al. Urgent ERCP with pancreatic stent placement or replacement for salvage of post-ERCP pancreatitis. Endoscopy 2014;46:1085-94.  Back to cited text no. 192
Salminen P, Laine S, Gullichsen R. Severe and fatal complications after ERCP: Analysis of 2555 procedures in a single experienced center. Surg Endosc 2008;22:1965-70.  Back to cited text no. 193
Pungpapong S, Kongkam P, Rerknimitr R, Kullavanijaya P. Experience on endoscopic retrograde cholangiopancreatography at tertiary referral center in Thailand: Risks and complications. J Med Assoc Thai 2005;88:238-46.  Back to cited text no. 194
Mazanikov M. Patient-controlled sedation for endoscopic retrograde cholangiopancreatography. 2013. Available from: https://helda.helsinki.fi/bitstream/handle/10138/39302/patientc.pdf?sequence=1. [Last accessed on 2018 Aug 06].  Back to cited text no. 195
Ong TZ, Khor JL, Selamat DS, Yeoh KG, Ho KY. Complications of endoscopic retrograde cholangiography in the post-MRCP era: A tertiary center experience. World J Gastroenterol 2005;11:5209-12.  Back to cited text no. 196
Stefanidis G, Viazis N, Pleskow D, Manolakopoulos S, Theocharis L, Christodoulou C, et al. Large balloon dilation vs. mechanical lithotripsy for the management of large bile duct stones: A prospective randomized study. Am J Gastroenterol 2011;106:278-85.  Back to cited text no. 197
Ferreira LE, Baron TH. Post-sphincterotomy bleeding: Who, what, when, and how. Am J Gastroenterol 2007;102:2850-8.  Back to cited text no. 198
Fujimoto K, Fujishiro M, Kato M, Higuchi K, Iwakiri R, Sakamoto C, et al. Guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment. Dig Endosc 2014;26:1-4.  Back to cited text no. 199
Veitch AM, Vanbiervliet G, Gershlick AH, Boustiere C, Baglin TP, Smith LA, et al. Endoscopy in patients on antiplatelet or anticoagulant therapy, including direct oral anticoagulants: British Society of Gastroenterology (BSG) and European society of Gastrointestinal Endoscopy (ESGE) guidelines. Gut 2016;65:374-89.  Back to cited text no. 200
Vitale GC, Rangnekar NJ, Hewlett SC. Advanced interventional endoscopy. Curr Probl Surg 2002;39:968-1053.  Back to cited text no. 201
Marks D, Harbord M. Emergencies in Gastroenterology and Hepatology. Oxford: OUP; 2013.  Back to cited text no. 202
Rey JF, Beilenhoff U, Neumann CS, Dumonceau JM; European Society of Gastrointestinal Endoscopy (ESGE). European society of gastrointestinal endoscopy (ESGE) guideline: The use of electrosurgical units. Endoscopy 2010;42:764-72.  Back to cited text no. 203
de Vries JH, Duijm LE, Dekker W, Guit GL, Ferwerda J, Scholten ET, et al. CT before and after ERCP: Detection of pancreatic pseudotumor, asymptomatic retroperitoneal perforation, and duodenal diverticulum. Gastrointest Endosc 1997;45:231-5.  Back to cited text no. 204
Wu HM, Dixon E, May GR, Sutherland FR. Management of perforation after endoscopic retrograde cholangiopancreatography (ERCP): A population-based review. HPB (Oxford) 2006;8:393-9.  Back to cited text no. 205
Howard TJ, Tan T, Lehman GA, Sherman S, Madura JA, Fogel E, et al. Classification and management of perforations complicating endoscopic sphincterotomy. Surgery 1999;126:658-63.  Back to cited text no. 206
Enns R, Eloubeidi MA, Mergener K, Jowell PS, Branch MS, Pappas TM, et al. ERCP-related perforations: Risk factors and management. Endoscopy 2002;34:293-8.  Back to cited text no. 207
Kayhan B, Akdoğan M, Sahin B. ERCP subsequent to retroperitoneal perforation caused by endoscopic sphincterotomy. Gastrointest Endosc 2004;60:833-5.  Back to cited text no. 208
English GR, Peitzman AB. The Complicated Cholecystectomy and Management of Perforation Post-ERCP, in Complications in Acute Care Surgery. Cham, Switzerland: Springer; 2017. p. 113-28.  Back to cited text no. 209
Norton ID, Petersen BT, Bosco J, Nelson DB, Meier PB, Baron TH, et al. A randomized trial of endoscopic biliary sphincterotomy using pure-cut versus combined cut and coagulation waveforms. Clin Gastroenterol Hepatol 2005;3:1029-33.  Back to cited text no. 210
Baron TH, Gostout CJ, Herman L. Hemoclip repair of a sphincterotomy-induced duodenal perforation. Gastrointest Endosc 2000;52:566-68.  Back to cited text no. 211
Paspatis GA, Dumonceau JM, Barthet M, Meisner S, Repici A, Saunders BP, et al. Diagnosis and management of iatrogenic endoscopic perforations: European society of gastrointestinal endoscopy (ESGE) position statement. Endoscopy 2014;46:693-711.  Back to cited text no. 212
Anastassiades CP, Wong RC. ERCP complications. In: Gastrointestinal Emergencies. Hoboken, NJ: John Wiley & Sons: 2016. p. 61.  Back to cited text no. 213
Ringold DA, Jonnalagadda S. Complications of therapeutic endoscopy: A review of the incidence, risk factors, prevention, and endoscopic management. Tech Gastrointest Endosc 2007;9:90-103.  Back to cited text no. 214
Marini T, Desai A, Kaproth-Joslin K, Wandtke J, Hobbs SK. Imaging of the oesophagus: Beyond cancer. Insights Imaging 2017;8:365-76.  Back to cited text no. 215
Smith CD. Esophageal strictures and diverticula. Surg Clin North Am 2015;95:669-81.  Back to cited text no. 216
Chokhavatia S, Alli-Akintade L, Harpaz N, Stern R. Esophageal pathology: A brief guide and atlas. Otolaryngol Clin North Am 2013;46:1043-57.  Back to cited text no. 217
Enterline H, Thompson J. Pathology of the Esophagus. New York, NY: Springer Science & Business Media; 2012.  Back to cited text no. 218
Machado NO. Management of duodenal perforation post-endoscopic retrograde cholangiopancreatography. When and whom to operate and what factors determine the outcome? A review article. JOP 2012;13:18-25.  Back to cited text no. 219
Avgerinos DV, Llaguna OH, Lo AY, Voli J, Leitman IM. Management of endoscopic retrograde cholangiopancreatography: Related duodenal perforations. Surg Endosc 2009;23:833-8.  Back to cited text no. 220
Baron TH, Wong Kee Song LM, Zielinski MD, Emura F, Fotoohi M, Kozarek RA, et al. A comprehensive approach to the management of acute endoscopic perforations (with videos). Gastrointest Endosc 2012;76:838-59.  Back to cited text no. 221
Madanick RD. Medical management of iatrogenic esophageal perforations. Curr Treat Options Gastroenterol 2008;11:54-63.  Back to cited text no. 222
Varadarajulu S, Noone TC, Tutuian R, Hawes RH, Cotton PB. Predictors of outcome in pancreatic duct disruption managed by endoscopic transpapillary stent placement. Gastrointest Endosc 2005;61:568-75.  Back to cited text no. 223
Fatima J, Baron TH, Topazian MD, Houghton SG, Iqbal CW, Ott BJ, et al. Pancreaticobiliary and duodenal perforations after periampullary endoscopic procedures: Diagnosis and management. Arch Surg 2007;142:448-54.  Back to cited text no. 224
Devière J. Who should receive antibiotic prophylaxis before ERCP? Nat Clin Pract Gastroenterol Hepatol 2008;5:594-5.  Back to cited text no. 225
De Palma GD, Galloro G, Siciliano S, Iovino P, Catanzano C. Unilateral versus bilateral endoscopic hepatic duct drainage in patients with malignant hilar biliary obstruction: Results of a prospective, randomized, and controlled study. Gastrointest Endosc 2001;53:547-53.  Back to cited text no. 226
Sherman S. Endoscopic drainage of malignant hilar obstruction: Is one biliary stent enough or should we work to place two? Gastrointest Endosc 2001;53:681-4.  Back to cited text no. 227
Dumonceau JM. Biliary ERCP. Endoscopy 2008;40:50-4.  Back to cited text no. 228
Yamashita Y, Takada T, Kawarada Y, Nimura Y, Hirota M, Miura F, et al. Surgical treatment of patients with acute cholecystitis: Tokyo guidelines. J Hepatobiliary Pancreat Surg 2007;14:91-7.  Back to cited text no. 229
Takada T, Strasberg SM, Solomkin JS, Pitt HA, Gomi H, Yoshida M, et al. TG13: Updated tokyo guidelines for the management of acute cholangitis and cholecystitis. J Hepatobiliary Pancreat Sci 2013;20:1-7.  Back to cited text no. 230
Mazuski JE, Tessier JM, May AK, Sawyer RG, Nadler EP, Rosengart MR, et al. The surgical infection society revised guidelines on the management of intra-abdominal infection. Surg Infect (Larchmt) 2017;18:1-76.  Back to cited text no. 231
Girotti ME, Gupta N, Schirmer BD, Sarti M, Choudhri AF, Arslan B, et al. Iatrogenic intramural dissection of the gallbladder wall can mimic post-ERCP cholecystitis. Endoscopy 2007;39 Suppl 1:E205-6.  Back to cited text no. 232
Levy I, Gralnek IM. Complications of diagnostic colonoscopy, upper endoscopy, and enteroscopy. Best Pract Res Clin Gastroenterol 2016;30:705-18.  Back to cited text no. 233
Eisen GM, Baron TH, Dominitz JA, Faigel DO, Goldstein JL, Johanson JF, et al. Complications of upper GI endoscopy. Gastrointest Endosc 2002;55:784-93.  Back to cited text no. 234
ASGE Standards of Practice Committee, Chandrasekhara V, Khashab MA, Muthusamy VR, Acosta RD, Agrawal D, et al. Adverse events associated with ERCP. Gastrointest Endosc 2017;85:32-47.  Back to cited text no. 235
Skelly M, Palmer D. Conscious Sedation: A Handbook for Nurse Practioners. Hoboken, NJ: John Wiley & Sons; 2006.  Back to cited text no. 236
Cohen J, Haber GB, Dorais JA, Scheider DM, Kandel GP, Kortan PP, et al. A randomized, double-blind study of the use of droperidol for conscious sedation during therapeutic endoscopy in difficult to sedate patients. Gastrointest Endosc 2000;51:546-51.  Back to cited text no. 237
Varadarajulu S, Eloubeidi MA, Tamhane A, Wilcox CM. Prospective randomized trial evaluating ketamine for advanced endoscopic procedures in difficult to sedate patients. Aliment Pharmacol Ther 2007;25:987-97.  Back to cited text no. 238
Alexiou K, Sakellaridis T, Sikalias N, Karanikas I, Economou N, Antsaklis G, et al. Subcutaneous emphysema, pneumomediastinum and pneumoperitoneum after unsuccessful ERCP: A case report. Cases J 2009;2:120.  Back to cited text no. 239
Rodríguez-González FJ, Naranjo-Rodríguez A, Mata-Tapia I, Chicano-Gallardo M, Puente-Gutierrez JJ, López-Vallejos P, et al. ERCP in patients 90 years of age and older. Gastrointest Endosc 2003;58:220-5.  Back to cited text no. 240
Sivagnanam P, Cheong E, Rhodes M. Delayed gallstone ileus presentation after ERCP and sphincterotomy. Gastrointest Endosc 2009;69:156-8.  Back to cited text no. 241
Williams IM, Hughes OD, Hicks E, Lewis MH. Gall stone ileus following multiple endoscopic retrograde cholangiopancreatographies. J R Coll Surg Edinb 1997;42:423.  Back to cited text no. 242
Lancaster JF, Strong RW, McIntyre A, Kerlin P. Gallstone ileus complicating endoscopic sphincterotomy. Aust N Z J Surg 1993;63:416-7.  Back to cited text no. 243
Pruitt A, Schutz SM, Baron T, McClendon D, Lang KA. Fractured hydrophilic guidewire during ERCP: A case series. Gastrointest Endosc 1998;48:77-80.  Back to cited text no. 244
Mutignani M, Gabbrielli A, Murali N, Perri V, Costamagna G. Novel methods of management of trapped dormia baskets in the pancreatic and biliary ducts. Endoscopy 1997;29:129-30.  Back to cited text no. 245
Heinerman M, Mann R, Boeckl O. An unusual complication in attempted non-surgical treatment of pancreatic bile duct stones. Endoscopy 1993;25:248-50.  Back to cited text no. 246
Jacob L, Geenen JE. ERCP guide wires. Gastrointest Endosc 1996;43:57-60.  Back to cited text no. 247


  [Figure 1], [Figure 2], [Figure 3]

  [Table 1], [Table 2], [Table 3]

This article has been cited by
1 Diagnostic value of endoscopic retrograde cholangiopancreatography and therapeutic value of endoscopic sphincterotomy in dogs with suspected hepatobiliary disorders
Vahideh Rahmani, Thomas Spillmann, Jorma Halttunen, Pernilla Syrjä, Mirja Ruohoniemi
BMC Veterinary Research. 2022; 18(1)
[Pubmed] | [DOI]


Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

  In this article
Endoscopic Retro...
Alternatives to ...
Quantifying the ...
Endoscopic Retro...
Endoscopic Retro...
Endoscopic Retro...
Overview of Endo...
Endoscopic Retro...
Medical Preventi...
Clinical Managem...
Post-Endoscopic ...
Enteric Perforat...
Cholangitis and ...
Cardiopulmonary ...
Miscellaneous Co...
Article Figures
Article Tables

 Article Access Statistics
    PDF Downloaded106    
    Comments [Add]    
    Cited by others 1    

Recommend this journal